[胆固醇和氢化可的松对氨基葡萄糖合成酶活性的调节]
[Regulation of glucosamine synthetase activity by cholesterol and hydrocortisone].
作者信息
Sharaev P N, Ivanov V G, Bogdanov N G
出版信息
Biokhimiia. 1988 Sep;53(9):1505-8.
PMID:3203113
Abstract
The effects of cholesterol and hydrocortisone (cortisol) on the activity of purified glucosamine synthetase from rat liver was studied in vitro. It was found that the enzyme activity is increased by cholesterol and inhibited by hydrocortisone. These steroids block the allosteric effect of vitamin K1 on the enzyme. There is evidence testifying to the allosteric type of cholesterol and hydrocortisone effects on glucosamine synthetase.
摘要
在体外研究了胆固醇和氢化可的松（皮质醇）对大鼠肝脏纯化的氨基葡萄糖合成酶活性的影响。发现该酶活性被胆固醇增强而被氢化可的松抑制。这些类固醇阻断了维生素K1对该酶的变构效应。有证据证明胆固醇和氢化可的松对氨基葡萄糖合成酶的作用属于变构类型。
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