Laudignon N, Chemtob S, Bard H, Aranda J V
Developmental Pharmacology and Perinatal Research Unit, McGill University, Montreal, Que., Canada.
Biol Neonate. 1988;54(5):254-62. doi: 10.1159/000242860.
Using the Doppler technique, the effect of therapeutic doses of indomethacin on the cerebral blood flow velocity (CBFV) of anterior cerebral arteries was studied in 13 preterm infants with patent ductus arteriosus. The first intravenous injection of indomethacin (0.2 mg/kg, group 1, n = 10) induced a significant decrease in the area under the velocity curve at 15 min (-22%), which was sustained until 120 min (-28%, p less than 0.005). In contrast, no significant change in CBFV occurred after the third dose (group 2, n = 7). In both groups, capillary blood gases, mean arterial blood pressure, and heart rate remained stable throughout the study. In 5 mechanically ventilated infants, the increase in CBFV secondary to suctioning was significantly attenuated after the first dose of indomethacin (p less than 0.02) but not after the third (p = 0.56). Thus, an initial dose of indomethacin may attenuate CBFV increases secondary to clinical manipulations in the preterm newborn.
采用多普勒技术，对13例动脉导管未闭的早产儿进行研究，观察治疗剂量的吲哚美辛对大脑前动脉脑血流速度（CBFV）的影响。首次静脉注射吲哚美辛（0.2mg/kg，第1组，n=10）后15分钟，速度曲线下面积显著下降（-22%），并持续至120分钟（-28%，p<0.005）。相比之下，第3次给药后CBFV无显著变化（第2组，n=7）。在两组中，整个研究过程中毛细血管血气、平均动脉血压和心率均保持稳定。在5例机械通气的婴儿中，首次注射吲哚美辛后，吸痰继发的CBFV增加显著减弱（p<0.02），但第3次注射后无此现象（p=0.56）。因此，初始剂量的吲哚美辛可能会减弱早产新生儿临床操作继发的CBFV增加。
