Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing Institute of Respiratory Medicine, Beijing, China.
Basic Medical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Clin Respir J. 2020 May;14(5):481-487. doi: 10.1111/crj.13158. Epub 2020 Feb 19.
Limited biomarkers are used for predicting risk of venous thromboembolism (VTE) associated with cancer. Circulating microparticles (MPs), especially tissue factor- positive microparticles (TF + MPs), play an important role in the development of cancer-associated VTE. This study investigated the predictive value of plasma MPs and TF + MPs for VTE in lung cancer.
A case-control study was performed using the Beijing Chao-Yang Hospital Lung Cancer Registry. Cases had VTE occurring 3 months before or after a diagnosis of lung cancer. Controls were patients with lung cancer without VTE matched for age, histology and stage. The proportion of MPs and TF + MPs was evaluated by light-scatter-based flow cytometry.
Between January 2012 and December 2015, 30 cases with VTE and 60 controls without VTE were included. The proportion of MPs and TF + MPs was significantly more elevated in patients with VTE than in those without VTE (P < 0.05 for both). By multivariate logistic regression analysis, MPs (OR 1.153; 95% CI 1.068-1.245; P < 0.001) and adenocarcinoma (OR 3.223; 95% CI 1.062-9.782; P = 0.039) were significantly associated with VTE. The sensitivity of the proportion of MPs in diagnosing VTE was 93.3%, and the specificity was 70.0%. The sensitivity of the proportion of TF + MPs in diagnosing VTE was 66.7%, and the specificity was 88.3%. The area under the receiver operating characteristic curves for the diagnostic of the proportion of MPs and TF + MPs values were 0.836 (95% CI 0.750-0.922, P < 0.001) and 0.828 (95% CI 0.736-0.920, P < 0.001) respectively.
The elevated proportion of MPs and TF + MPs might help predict VTE associated with lung cancer.
目前用于预测癌症相关静脉血栓栓塞症（VTE）风险的生物标志物有限。循环微颗粒（MPs），尤其是组织因子阳性微颗粒（TF+MPs），在癌症相关 VTE 的发生发展中发挥着重要作用。本研究旨在探讨血浆 MPs 和 TF+MPs 对肺癌患者 VTE 的预测价值。
采用北京朝阳医院肺癌登记处的病例对照研究。病例为肺癌诊断前 3 个月或诊断后 3 个月内发生 VTE 的患者。对照组为年龄、组织学和分期相匹配的无 VTE 的肺癌患者。采用基于光散射的流式细胞术评估 MPs 和 TF+MPs 的比例。
2012 年 1 月至 2015 年 12 月期间，共纳入 30 例 VTE 患者和 60 例无 VTE 患者。VTE 患者 MPs 和 TF+MPs 的比例明显高于无 VTE 患者（均 P<0.05）。多变量 logistic 回归分析显示， MPs（OR 1.153；95%CI 1.068-1.245；P<0.001）和腺癌（OR 3.223；95%CI 1.062-9.782；P=0.039）与 VTE 显著相关。 MPs 比例诊断 VTE 的敏感度为 93.3%，特异度为 70.0%。TF+MPs 比例诊断 VTE 的敏感度为 66.7%，特异度为 88.3%。 MPs 和 TF+MPs 比值的受试者工作特征曲线下面积分别为 0.836（95%CI 0.750-0.922，P<0.001）和 0.828（95%CI 0.736-0.920，P<0.001）。
MPs 和 TF+MPs 比例的升高可能有助于预测肺癌相关的 VTE。
