Kuster Irina, Valdec Silvio, Rücker Martin, Bichsel Dominique
Klinik für Mund-, Kiefer- und Gesichtschirurgie, Poliklinik für Oralchirurgie, Universitätsspital Zürich, Universität Zürich, Schweiz
Swiss Dent J. 2020 Feb 10;130(2):139-145. doi: 10.61872/sdj-2020-02-02.
Antiresorptive drugs are increasingly used for the treatment of osteoporosis, various bone pathologies and malignant tumors. Antiresorptive agent-related osteonecrosis of the jaw (ARONJ) is a relevant complication, especially in nonhealing extraction sockets. Prescription of antibiotics in combination with a safely guaranteed closure of the extraction socket is considerably reducing the risk of ARONJ development. Full mucosal coverage usually requires the formation of a full thickness flap, which involves periosteal disclosure of the remodeled bone. In this new approach, primary wound closure is performed by covering the extraction socket with a xenogeneic collagen matrix. Ultimately, elevation of a periosteal flap and additional exposure of the surrounding alveolar bone is avoidable. The technique is exemplified on a patient case with a perennial anti resorptive medication history.
抗吸收药物越来越多地用于治疗骨质疏松症、各种骨病和恶性肿瘤。抗吸收剂相关的颌骨坏死（ARONJ）是一种相关并发症，尤其是在拔牙创不愈合的情况下。联合使用抗生素并确保拔牙创安全闭合可显著降低ARONJ发生的风险。完全覆盖黏膜通常需要形成全厚瓣，这涉及对重塑骨进行骨膜暴露。在这种新方法中，通过用异种胶原基质覆盖拔牙创来进行一期伤口闭合。最终，避免了掀起骨膜瓣和额外暴露周围牙槽骨。该技术以一位有长期抗吸收药物治疗史的患者病例为例进行说明。
