Rorie D K, Tyce G M
Department of Anesthesiology, Mayo Clinic, Rochester, Minn.
Blood Vessels. 1988;25(6):265-72. doi: 10.1159/000158740.
These studies address the apparent dissociation between the amounts of norepinephrine (NE) released from small and large pulmonary arteries of dogs by a standard electrical stimulus and the contractile tensions that developed in these tissues. Segments of vessels were studied in organ baths or in a superfusion apparatus during electrical stimulation. Endogenous NE was quantitated using liquid chromatography with electrochemical detection. 'Release' of NE was studied under conditions in which uptakes of NE from the synaptic cleft were impaired, and overflow of NE was studied when these uptakes were operative. 'Release' of NE was predictably greater than overflow in all arteries. In the large pulmonary artery, greater contractile tensions were measured when greater amounts of NE were present in superfusate. In the small pulmonary artery, contractile tensions did not directly correlate with the amounts of NE measured in the superfusate. These studies indicate that NE dynamics are different at neuroeffector junctions in large and small pulmonary arteries. Several explanations to account for these differences are discussed.
这些研究探讨了通过标准电刺激从犬的小肺动脉和大肺动脉释放的去甲肾上腺素（NE）量与这些组织中产生的收缩张力之间明显的解离现象。在电刺激期间，在器官浴或灌注装置中研究血管段。使用带有电化学检测的液相色谱法定量内源性NE。在NE从突触间隙的摄取受损的条件下研究NE的“释放”，并在这些摄取起作用时研究NE的溢出。在所有动脉中，NE的“释放”可预测地大于溢出。在大肺动脉中，当灌注液中存在更多量的NE时，测量到更大的收缩张力。在小肺动脉中，收缩张力与灌注液中测量到的NE量没有直接相关性。这些研究表明，大、小肺动脉神经效应器连接处的NE动态不同。讨论了几种解释这些差异的原因。
