Scharf Jackson M, Hilely Assaf, Freund K Bailey, Sarraf David
Retina Disorders and Ophthalmic Genetics, Stein Eye Institute, University of California-Los Angeles, Los Angeles, California.
Vitreous Retina Macula Consultants of New York, New York, New York; and.
Retin Cases Brief Rep. 2022 May 1;16(3):280-284. doi: 10.1097/ICB.0000000000000974. Epub 2020 Feb 5.
To describe the recovery timeline of spots and dots in multiple evanescent white dot syndrome.
Sequential multimodal retinal imaging including fundus autofluorescence and cross-sectional and en face optical coherence tomography was performed to track the development and resolution of spots and dots in a case of multiple evanescent white dot syndrome.
En face optical coherence tomography showed that the spots are the result of ellipsoid zone loss and are hyperautofluorescent due to unmasking of the underlying retinal pigment epithelium autofluorescence. Conversely, the dots are hyperreflective with cross-sectional and en face optical coherence tomography and hyperautofluorescent, which we propose may be due to accumulation of degenerated photoreceptor material including fluorophores with autofluorescent capability such as precursors of A2E. The earlier resolution of the hyperautofluorescent spots allowed for later detection of the hyperautofluorescent dots.
This case report illustrates the different recovery timelines of spots and dots in multiple evanescent white dot syndrome. Although both lesion types are hyperautofluorescent, the mechanism of autofluorescence is distinctive and may be explained by their contrasting pathoanatomy.
描述多发性一过性白点综合征中白点和斑点的恢复时间线。
对一例多发性一过性白点综合征患者进行包括眼底自发荧光以及横断面和表面光学相干断层扫描在内的连续多模态视网膜成像，以追踪白点和斑点的发展及消退情况。
表面光学相干断层扫描显示，白点是椭圆体带缺失的结果，由于下方视网膜色素上皮自发荧光的暴露而呈现高自发荧光。相反，斑点在横断面和表面光学相干断层扫描中表现为高反射性且高自发荧光，我们认为这可能是由于包括具有自发荧光能力的荧光团（如A2E的前体）在内的退化光感受器物质的积累所致。高自发荧光白点的较早消退使得高自发荧光斑点能在更晚的时候被检测到。
本病例报告说明了多发性一过性白点综合征中白点和斑点不同的恢复时间线。尽管两种病变类型均为高自发荧光，但自发荧光的机制不同，这可能由它们截然不同的病理解剖结构来解释。
