J Refract Surg. 2020 Feb 1;36(2):104-109. doi: 10.3928/1081597X-20191217-01.
To evaluate vision and corneal surface regularity after each step of a three-step surgical treatment of keratoconus and post-laser in situ keratomileusis (LASIK) ectasia (implantation of intracorneal ring segments [ICRS], corneal cross-linking [CXL], and implantation of toric intraocular contact lenses [ICLs]).
Thirty-one eyes of 24 patients with moderate to severe keratoconus and post-LASIK ectasia (stages II and III of Amsler-Krumeich classification) were included. All eyes underwent all three steps. The time interval between ICRS implantation and CXL was 4 to 6 weeks, and ICL implantation was performed 6 to 8 months after CXL. Visual acuity, refraction, and corneal topometric indices were evaluated with the Pentacam system (index of surface variance [ISV], index of vertical asymmetry [IVA], keratoconus index [KI], central keratoconus index [CKI], index of height asymmetry [IHA], index of height decentration [IHD], and corneal wavefront parameters [eg, higher order aberrations, spherical aberration, and coma]).
Decimal uncorrected distance visual acuity (UDVA) improved from 0.13 ± 0.17 preoperatively to 0.69 ± 0.18 at 1 year, whereas corrected distance visual acuity (CDVA) improved from 0.56 ± 0.24 to 0.80 ± 0.18, respectively. The topometric indices ISV, IVA, KI, and IHD also improved significantly, whereas CKI and IHA showed no significant improvement. Higher order aberrations, spherical aberration, and coma improved significantly compared to baseline.
The combined use of ICRS, CXL, and ICL implantation significantly improves visual acuity, higher order aberrations, and corneal shape in moderate and severe keratoconus and post-LASIK ectasia. [J Refract Surg. 2020;36(2):104-109.].
评估三步法治疗圆锥角膜和 LASIK 后扩张性角膜病变(角膜交联术[CXL]和植入式环段性角膜内植入术[ICRS])后每一步手术对视力和角膜表面规则性的影响。
纳入 24 例 31 只眼的中重度圆锥角膜和 LASIK 后扩张性角膜病变患者(Amsler-Krumeich 分类的 II 期和 III 期)。所有患者均接受了这三种手术治疗。ICRS 植入和 CXL 之间的时间间隔为 4 至 6 周,CXL 后 6 至 8 个月植入 T 型 ICL。采用 Pentacam 系统(表面不规则指数[ISV]、垂直非对称指数[IVA]、圆锥角膜指数[KI]、中央角膜圆锥指数[CKI]、高度非对称指数[IHA]、高度偏心指数[IHD]和角膜波前参数[高阶像差、球差和彗差])评估视力、屈光度和角膜地形指数。
十进制未矫正远视力(UDVA)从术前的 0.13 ± 0.17 提高到 1 年后的 0.69 ± 0.18,而矫正远视力(CDVA)从 0.56 ± 0.24 提高到 0.80 ± 0.18。ISV、IVA、KI 和 IHD 等地形指数也显著改善,而 CKI 和 IHA 无明显改善。与基线相比,高阶像差、球差和彗差显著改善。
联合使用 ICRS、CXL 和 ICL 植入术可显著改善中重度圆锥角膜和 LASIK 后扩张性角膜病变患者的视力、高阶像差和角膜形态。