J Refract Surg. 2020 Feb 1;36(2):118-122. doi: 10.3928/1081597X-20200115-01.
To investigate possible refractive changes in pregnant women who have previously undergone myopic laser in situ keratomileusis (LASIK).
This prospective study included 64 pregnant women (128 eyes) who had previously undergone bilateral myopic LASIK. Uncorrected distance visual acuity (UDVA), spherical equivalent, corneal keratometry, topography and tomography, and epithelial mapping were evaluated before LASIK, 12 months after LASIK, during the third trimester of pregnancy, and 1 year postpartum.
The average age at the time of recruitment was 32.5 ± 5 years (range: 24.5 to 39.5 years). The evaluation during pregnancy was at an average 55 months (range: 12 to 108 months) from the initial LASIK procedure. The preoperative mean refractive error was -6.72 ± 2.96 diopters (D) (range: -1.00 to -11.00 D). Comparing 12-month refractive data after the original LASIK procedure to the those within the third trimester of the subsequent pregnancy, the average UDVA was 20/18, the residual refractive error was -0.63 ± 1.00 to -0.51 ± 0.82 D, the steepest keratometry value was 40.85 ± 1.89 to 40.88 ± 2.84 D, and the central epithelial thickness was 56.4 ± 3.89 to 57.38 ± 5.04 µm, respectively.
In this study, pregnancy did not affect the refractive stability of LASIK. Pregnancy-related changes in refractive error, corneal stability, and total corneal and epithelial thickness in women after LASIK were not found to be statistically significant. [J Refract Surg. 2022;36(2):118-122.].
研究先前接受过近视激光原位角膜磨镶术（LASIK）的孕妇可能出现的屈光变化。
本前瞻性研究纳入了 64 名（128 只眼）先前接受过双侧近视 LASIK 的孕妇。在 LASIK 之前、LASIK 后 12 个月、妊娠晚期和产后 1 年，评估未矫正远视力（UDVA）、等效球镜、角膜曲率计、地形图和断层扫描以及上皮图。
招募时的平均年龄为 32.5±5 岁（范围：24.5 至 39.5 岁）。妊娠期间的评估距离初始 LASIK 手术的平均时间为 55 个月（范围：12 至 108 个月）。术前平均屈光误差为-6.72±2.96 屈光度（D）（范围：-1.00 至-11.00 D）。与原始 LASIK 手术后 12 个月的屈光数据相比，在随后妊娠的晚期，平均 UDVA 为 20/18，残留屈光误差为-0.63±1.00 至-0.51±0.82 D，最陡角膜曲率值为 40.85±1.89 至 40.88±2.84 D，中央上皮厚度分别为 56.4±3.89 至 57.38±5.04 µm。
在这项研究中，妊娠并未影响 LASIK 的屈光稳定性。在 LASIK 后女性中，未发现与妊娠相关的屈光不正、角膜稳定性以及总角膜和上皮厚度变化具有统计学意义。[J Refract Surg. 2022;36(2):118-122.]。
