Truver Michael T, Swortwood-Gates Madeleine J
Department of Forensic Science, College of Criminal Justice, Sam Houston State University, Huntsville, TX, USA.
Department of Forensic Science, College of Criminal Justice, Sam Houston State University, Huntsville, TX, USA.
Forensic Sci Int. 2020 Mar;308:110175. doi: 10.1016/j.forsciint.2020.110175. Epub 2020 Jan 29.
Recently, there has been an increase in overdose deaths due to novel synthetic opioids (NSO). Due to backlogs experienced by many forensic laboratories, it is important to understand drug stability in a variety of storage conditions. The objective of this study was to investigate the stability of AH-7921, U-47700, U-49900, U-50488, MT-45, W-15, and W-18 in blood at various temperatures over a 36-week period. NSO were generally stable over the 36-week period (66%-118%) at low and high concentrations when blood samples were stored in the refrigerator or freezer. Most analytes were stable for at least 2 weeks at room temperature (77%-120%). At the elevated temperature (35°C), analytes were generally stable for at least 14 days (75%-109%). This study has determined the stability of several NSO at various temperatures over a 36-week period. These results reflect the forensic significance of keeping samples stored at proper temperatures. Blood samples suspected to contain synthetic opioids should be stored refrigerated or frozen, when possible, in order to preserve analyte stability, especially at low concentrations.
最近，新型合成阿片类药物（NSO）导致的过量用药死亡人数有所增加。由于许多法医实验室存在积压情况，了解药物在各种储存条件下的稳定性很重要。本研究的目的是调查AH - 7921、U - 47700、U - 49900、U - 50488、MT - 45、W - 15和W - 18在血液中于不同温度下36周内的稳定性。当血液样本储存在冰箱或冰柜中时，NSO在36周内低浓度和高浓度时通常都很稳定（66% - 118%）。大多数分析物在室温下至少2周内稳定（77% - 120%）。在高温（35°C）下，分析物通常至少14天稳定（75% - 109%）。本研究确定了几种NSO在36周内不同温度下的稳定性。这些结果反映了将样本保存在适当温度下的法医意义。怀疑含有合成阿片类药物的血液样本应尽可能冷藏或冷冻保存，以保持分析物的稳定性，尤其是在低浓度时。
