Iurlo A, Mecucci C, Van Orshoven A, Michaux J L, Boogaerts M, Van den Berghe H
Center for Human Genetics, University of Leuven, Belgium.
Cancer Genet Cytogenet. 1988 Dec;36(2):165-72. doi: 10.1016/0165-4608(88)90140-9.
In 19 cases of secondary hematologic disorders in patients previously treated for Hodgkin's disease, chromosome aberrations were analyzed in relation to the type of previous chemo- and/or radiotherapy, age of the patients, histopathologic features of the Hodgkin's disease at diagnosis, time interval between the treatment and the occurrence of the secondary disorder, and survival. The karyotype was of significant prognostic value when three cytogenetic groups were considered: patients with normal karyotypes; patients with aberrations of chromosome 7 as the sole anomaly; and patients with complex rearrangements and translocations. The last group showed the lowest rate of survival. Bone marrow transplantation was successful in two patients with a normal karyotype.
