Carneiro P C, Pereira E D, Mitteldorf C S, Martinez G A, Beitler B, Pozzi D H
Rev Hosp Clin Fac Med Sao Paulo. 1989 Mar-Apr;44(2):87-90.
The development of acute leukemia, particularly acute myeloid leukemia, represents a serious complication in patients treated with radio and/or chemotherapy for Hodgkin's disease. It has been reported with increasing frequency in the last years. Two such cases, that occurred in 87 patients treated for Hodgkin's disease, are reported. Complete autopsy was performed in both. The patients were less than 30 years old, received combined therapy during a prolonged time (more than 12 months), with an interval superior to 44 months between the diagnosis of Hodgkin's disease and the appearance of acute myeloid leukemia. The survival time was less than 12 months. Residual Hodgkin's disease was not observed.
急性白血病，尤其是急性髓系白血病的发生，是霍奇金淋巴瘤患者接受放疗和/或化疗时出现的一种严重并发症。近年来其报道频率不断增加。本文报告了在87例接受霍奇金淋巴瘤治疗的患者中发生的2例此类病例。对这2例均进行了完整的尸检。患者年龄小于30岁，接受了长时间（超过12个月）的联合治疗，从霍奇金淋巴瘤诊断到急性髓系白血病出现的间隔超过44个月。生存时间小于12个月。未观察到残留的霍奇金淋巴瘤。
