Photochemical oxidation of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (Emorfazone) by pyrimido[5,4-g]pteridine 5-oxide. An attempt to apply a functional chemical model for biological oxidations to drug-metabolism studies.
作者信息
Maki Y, Shimada K, Sako M, Kitade Y, Hirota K
出版信息
Chem Pharm Bull (Tokyo). 1988 May;36(5):1714-20. doi: 10.1248/cpb.36.1714.
PMID:3203412
Abstract
摘要
相似文献
1
Photochemical oxidation of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (Emorfazone) by pyrimido[5,4-g]pteridine 5-oxide. An attempt to apply a functional chemical model for biological oxidations to drug-metabolism studies.嘧啶并[5,4-g]蝶啶5-氧化物对4-乙氧基-2-甲基-5-吗啉基-3(2H)-哒嗪酮（吗啉乙苯酮）的光化学氧化。将生物氧化的功能化学模型应用于药物代谢研究的尝试。
Chem Pharm Bull (Tokyo). 1988 May;36(5):1714-20. doi: 10.1248/cpb.36.1714.
2
Metabolism of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (emorfazone). V. Effect of inducer pretreatment on oxygenation of the morpholino moiety in guinea pigs.4-乙氧基-2-甲基-5-吗啉代-3(2H)-哒嗪酮（吗啉乙吗啡）的代谢。V. 诱导剂预处理对豚鼠中吗啉代部分氧化作用的影响。
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[Studies on pyridazinone derivatives. XVI. Analgesic-antiinflammatory activities of 3(2H)-pyridazinone derivatives].
Yakugaku Zasshi. 1994 Feb;114(2):94-110. doi: 10.1248/yakushi1947.114.2_94.
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Metabolism of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101), a new anti-inflammatory agent. II. Species differences of metabolism and excretion.新型抗炎药4-乙氧基-2-甲基-5-吗啉代-3(2H)-哒嗪酮（M73101）的代谢。II. 代谢与排泄的种属差异
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[Studies on the syntheses of N-heterocyclic compounds. IX. On the reduction of 2-aryl-5,8-disubstituted pyrimido(4,5-d)pyridazine].[氮杂环化合物的合成研究。IX。关于2-芳基-5,8-二取代嘧啶并[4,5-d]哒嗪的还原]
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Metabolism of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone(M73101), A New anti-inflammatory agent. I. Identification of the metabolites in rabbit and their pharmacological studies.新型抗炎药4-乙氧基-2-甲基-5-吗啉代-3(2H)-哒嗪酮（M73101）的代谢。I. 兔体内代谢产物的鉴定及其药理研究
Chem Pharm Bull (Tokyo). 1978 Oct;26(10):3124-34. doi: 10.1248/cpb.26.3124.
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[Studies on pyridazinone derivatives. VII. Synthesis of urinary metabolites of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101) in human (author's transl)].哒嗪酮衍生物的研究。VII. 4-乙氧基-2-甲基-5-吗啉基-3(2H)-哒嗪酮（M73101）在人体内的尿液代谢产物的合成（作者译）
Yakugaku Zasshi. 1978 Nov;98(10):1421-7. doi: 10.1248/yakushi1947.98.10_1421.
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[Metabolism of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101), a new anti-inflammatory agent. IV. Plasma concentration and absorption in various animals (author's transl)].新型抗炎药4-乙氧基-2-甲基-5-吗啉基-3（2H）哒嗪酮（M73101）的代谢。IV. 不同动物的血浆浓度及吸收情况（作者译）
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Studies on mechanisms of action of emorfazone. Effects on the release of bradykinin-like substance in thermic edema of rat paws.依托芬那酯作用机制的研究。对大鼠足热肿中缓激肽样物质释放的影响。
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Synthesis and analgesic activity of some 4,6-disubstituted-3(2H)-pyridazinone derivatives.某些4,6-二取代-3(2H)-哒嗪酮衍生物的合成与镇痛活性
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