UHRF1在甲基化调控和血管生成中的作用
[Role of UHRF1 in methylation regulation and angiogenesis].
作者信息
Guo Zi, Mo Zhaohui
机构信息
Department of Endocrinology, the Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2020 Feb 10;37(2):200-204. doi: 10.3760/cma.j.issn.1003-9406.2020.02.025.
Many recent studies have proved that ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an important nuclear protein associated with tumorigenesis, which plays a significant role in epigenetic regulation, especially in DNA methylation and histone methylation. For its particular domains, UHRF1 plays a critical role in biological behaviors including cell proliferation, cell cycle, and apoptosis. Overexpression of UHRF1 in various tumors is closely associated with the angiogenesis in tumors. This paper will provide a review of the regulation of UHRF1 in DNA methylation and histone methylation, and discuss the potential epigenetic role of UHRF1 in angiogenesis.
许多近期研究已证明，含 PHD 和 RING 指结构域的类泛素蛋白 1（UHRF1）是一种与肿瘤发生相关的重要核蛋白，其在表观遗传调控中发挥重要作用，尤其是在 DNA 甲基化和组蛋白甲基化方面。由于其特定结构域，UHRF1 在包括细胞增殖、细胞周期和细胞凋亡等生物学行为中起关键作用。UHRF1 在各种肿瘤中的过表达与肿瘤血管生成密切相关。本文将综述 UHRF1 在 DNA 甲基化和组蛋白甲基化中的调控作用，并探讨 UHRF1 在血管生成中潜在的表观遗传作用。
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