Woodhouse K W, Wynne H A
Department of Medicine (Geriatrics), University of Newcastle upon Tyne, England.
Clin Pharmacokinet. 1988 Nov;15(5):287-94. doi: 10.2165/00003088-198815050-00002.
The propensity of elderly people to suffer from dose-dependent adverse drug reactions is well known. This may be largely related to reduced drug clearance. Changes in liver size and liver blood flow are probably the main reason for this decline in drug elimination with age. This review focuses on methods of measuring liver size and blood flow, on changes which have been reported in the elderly and on the clinical implications of these changes.
老年人易发生剂量依赖性药物不良反应，这是众所周知的。这可能在很大程度上与药物清除率降低有关。肝脏大小和肝血流量的变化可能是药物消除随年龄下降的主要原因。本综述重点关注肝脏大小和血流量的测量方法、老年人中已报道的变化以及这些变化的临床意义。
