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干细胞供者登记工作中的免疫遗传学：DKMS 范例（第 2 部分）。

Immunogenetics in stem cell donor registry work: The DKMS example (Part 2).

机构信息

DKMS, Tübingen, Germany.

DKMS Life Science Lab, Dresden, Germany.

出版信息

Int J Immunogenet. 2020 Apr;47(2):139-148. doi: 10.1111/iji.12479. Epub 2020 Feb 7.

DOI:10.1111/iji.12479
PMID:32034894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7079094/
Abstract

DKMS is a leading stem cell donor registry with more than 9 million donors. Donor registry activities share many touch points with topics from immunogenetics or population genetics. In this two-part review article, we deal with these aspects of donor registry work by using the example of DKMS. In the second part of the review, we focus on donor typing of non-HLA genes, the impact of donor age, gender and CMV serostatus on donation probabilities, the identification of novel HLA, KIR and MIC alleles by high-throughput donor typing, the activities of the Collaborative Biobank and pharmacogenetics in the donor registry context.

摘要

DKMS 是一家领先的干细胞捐献者注册机构，拥有超过 900 万名捐献者。捐献者注册活动与免疫遗传学或群体遗传学的许多主题有很多共同之处。在这篇由两部分组成的综述文章中，我们将使用 DKMS 的例子来处理这些方面的捐献者注册工作。在综述的第二部分中，我们重点介绍非 HLA 基因的供者分型、供者年龄、性别和 CMV 血清状态对供者概率的影响、通过高通量供者分型鉴定新的 HLA、KIR 和 MIC 等位基因、协作生物库和供者注册环境中的药物遗传学活动。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a955/7079094/40efa5333020/IJI-47-139-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a955/7079094/504a64b8ef65/IJI-47-139-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a955/7079094/2b84bc240563/IJI-47-139-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a955/7079094/b750ab43da03/IJI-47-139-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a955/7079094/40efa5333020/IJI-47-139-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a955/7079094/504a64b8ef65/IJI-47-139-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a955/7079094/2b84bc240563/IJI-47-139-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a955/7079094/b750ab43da03/IJI-47-139-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a955/7079094/40efa5333020/IJI-47-139-g004.jpg

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本文引用的文献

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Front Immunol. 2020 Mar 12;11:429. doi: 10.3389/fimmu.2020.00429. eCollection 2020.
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Common, intermediate and well-documented HLA alleles in world populations: CIWD version 3.0.0.世界人群中常见、中等频率且记录完善的HLA等位基因：CIWD版本3.0.0
HLA. 2020 Jun;95(6):516-531. doi: 10.1111/tan.13811. Epub 2020 Jan 31.
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External validation of models for KIR2DS1/KIR3DL1-informed selection of hematopoietic cell donors fails.模型用于 KIR2DS1/KIR3DL1 指导的造血细胞供者选择的外部验证失败。
HLA 错配非亲缘供者的存在缩小了供者来源的差距，而与受者的种族无关。
Transplant Cell Ther. 2023 Nov;29(11):686.e1-686.e8. doi: 10.1016/j.jtct.2023.08.014. Epub 2023 Aug 14.
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HLA-DQ heterodimers in hematopoietic cell transplantation.HLA-DQ 异二聚体在造血细胞移植中的作用。
Blood. 2022 May 19;139(20):3009-3017. doi: 10.1182/blood.2022015860.
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Haplotype Motif-Based Models for KIR-Genotype Informed Selection of Hematopoietic Cell Donors Fail to Predict Outcome of Patients With Myelodysplastic Syndromes or Secondary Acute Myeloid Leukemia.基于单倍型基序的模型用于基于 KIR 基因型的造血细胞供者选择，无法预测骨髓增生异常综合征或继发性急性髓系白血病患者的结局。
Front Immunol. 2021 Jan 19;11:584520. doi: 10.3389/fimmu.2020.584520. eCollection 2020.
Blood. 2020 Apr 16;135(16):1386-1395. doi: 10.1182/blood.2019002887.
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Int J Immunogenet. 2020 Feb;47(1):13-23. doi: 10.1111/iji.12471. Epub 2020 Jan 6.
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Donor HLA-E Status Associates with Disease-Free Survival and Transplant-Related Mortality after Non In Vivo T Cell-Depleted HSCT for Acute Leukemia.供者 HLA-E 状态与非体外 T 细胞耗竭 HSCT 治疗急性白血病后的无病生存和移植相关死亡率相关。
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