通过调节细胞氧化还原状态控制肿瘤血管生成和转移。
Control of tumor angiogenesis and metastasis through modulation of cell redox state.
机构信息
Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, E-29071 Málaga, Spain.
Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, E-29071 Málaga, Spain; IBIMA (Biomedical Research Institute of Málaga), E-29071 Málaga, Spain; CIBER de Enfermedades Raras (CIBERER), E-29071 Málaga, Spain.
出版信息
Biochim Biophys Acta Rev Cancer. 2020 Apr;1873(2):188352. doi: 10.1016/j.bbcan.2020.188352. Epub 2020 Feb 5.
Redox reactions pervade all biology. The control of cellular redox state is essential for bioenergetics and for the proper functioning of many biological functions. This review traces a timeline of findings regarding the connections between redox and cancer. There is ample evidence of the involvement of cellular redox state on the different hallmarks of cancer. Evidence of the control of tumor angiogenesis and metastasis through modulation of cell redox state is reviewed and highlighted.
氧化还原反应普遍存在于所有生物学中。细胞氧化还原状态的控制对于生物能量学和许多生物功能的正常运作至关重要。本综述追溯了关于氧化还原与癌症之间联系的发现时间线。有充分的证据表明细胞氧化还原状态参与了癌症的不同特征。通过调节细胞氧化还原状态来控制肿瘤血管生成和转移的证据也得到了综述和强调。
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