Mentges B, Rumpelt H J, Brückner R, Grüssner R, Risse-Eissfeller E M
Klinik und Poliklinik für Allgemein- und Abdominalchirurgie, Johannes-Gutenberg-Universität Mainz.
Chirurg. 1988 Jun;59(6):425-31.
The histopathological grading exerted a significant influence on prognosis in patients with colonic carcinoma. More than half of the well differentiated tumors were found in early stage pT1-3 N0 M0 compared to 25% of the G2- and 10% of the G3-tumors. The percentage of incurable cases in G2-tumors was twice as high and in G3-tumors three times as high as in patients with well differentiated carcinomas. The recurrence rate increased significantly with decreasing tumor differentiation from 21% to 51%. Despite the correlation with tumor stage the histopathological grading could be established as an independent prognostic variable and had an influence on the recurrence rate especially within tumor stage pT1-3 N0 M0.
组织病理学分级对结肠癌患者的预后有显著影响。与G2级肿瘤的25%和G3级肿瘤的10%相比，超过一半的高分化肿瘤处于早期pT1-3 N0 M0期。G2级肿瘤中不可治愈病例的百分比是高分化癌患者的两倍，G3级肿瘤是三倍。随着肿瘤分化程度降低，复发率从21%显著增加到51%。尽管与肿瘤分期相关，但组织病理学分级可被确立为独立的预后变量，尤其在pT1-3 N0 M0肿瘤分期内对复发率有影响。
