Gunay Emrah, Oncul Hasan
Department of Nephrology, University of Health Sciences, Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey.
Department of Ophthalmology, University of Health Sciences, Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey.
Transplant Proc. 2020 Mar;52(2):622-624. doi: 10.1016/j.transproceed.2019.12.005. Epub 2020 Feb 6.
Kaposi sarcoma (KS) is the most common tumor in patients with human immunodeficiency virus (HIV), and its frequency is increasing after organ transplantation in HIV-negative patients. A 28-year-old woman had preemptive kidney transplantation from her 48-year-old mother. In the postoperative ninth month, an exophytic mass was found in the upper medial conjunctiva of the right eye. The lesion was excised under local anesthesia, and cryotherapy was applied to the surgical area. The biopsy result was reported as KS. Treatment with tacrolimus was switched to everolimus (EVO), but EVO was discontinued because of pneumonitis. The patient was followed without any recurrences after the excision of the conjunctival lesion. No local or systemic recurrence was observed in the 14th month after surgical excision and local cryotherapy. Local treatment and the reduction of immunosuppressive therapy may be effective in the treatment of conjunctival KS.
卡波西肉瘤(KS)是人类免疫缺陷病毒(HIV)感染者中最常见的肿瘤,在HIV阴性患者接受器官移植后其发病率也在上升。一名28岁女性接受了来自其48岁母亲的先发制肾移植。术后第九个月,右眼上内侧结膜发现一个外生性肿物。在局部麻醉下切除病变,并对手术区域进行冷冻治疗。活检结果报告为KS。将他克莫司治疗改为依维莫司(EVO),但因肺炎停用EVO。结膜病变切除后对患者进行随访,无任何复发。手术切除和局部冷冻治疗后第14个月未观察到局部或全身复发。局部治疗和减少免疫抑制治疗可能对结膜KS的治疗有效。