Laboratory of Immune Regulation, Immunology Frontier Research Center, Osaka University, Osaka 565 0871, Japan; Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur 342005, India.
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Trends Immunol. 2020 Mar;41(3):255-268. doi: 10.1016/j.it.2020.01.004. Epub 2020 Feb 5.
AT-rich interactive domain 5A (ARID5A/Arid5a) is a known cofactor of transcription factors (TFs) that contributes to cell growth and differentiation. It has recently been recognized for its unique function in the stabilization of mRNA, which is associated with inflammatory autoimmune diseases. Studies have revolutionized our understanding of the post-transcriptional regulation of inflammatory genes by revealing the fundamental events underpinning novel functions and activities of Arid5a. We review current research on Arid5a, which has focused our attention towards the therapeutic potential of this factor in the putative treatment of inflammatory and autoimmune disorders, including experimental autoimmune encephalomyelitis and sepsis in mice.
富含 AT 的相互作用结构域 5A（ARID5A/Arid5a）是转录因子（TFs）的已知辅助因子，有助于细胞生长和分化。最近，它因其在 mRNA 稳定方面的独特功能而受到关注，这与炎症性自身免疫性疾病有关。研究通过揭示 Arid5a 的新功能和新活动的基本事件，彻底改变了我们对炎症基因转录后调控的理解。我们回顾了目前对 Arid5a 的研究，这引起了我们对该因子在炎症性和自身免疫性疾病（包括实验性自身免疫性脑脊髓炎和小鼠败血症）潜在治疗中的治疗潜力的关注。
