巴西儿科人群中非结核分枝杆菌感染：一项为期七年的调查。
Nontuberculous mycobacterial infections in a Brazilian pediatric population: a seven-year survey.
机构信息
Center for Investigation in Pediatrics, School of Medical Sciences, University of Campinas, Campinas, Brazil.
Department of Pediatrics, School of Medical Sciences, University of Campinas, Campinas, Brazil.
出版信息
Pathog Glob Health. 2020 Mar;114(2):104-108. doi: 10.1080/20477724.2020.1725330. Epub 2020 Feb 8.
The aim of this study was to describe the frequency of nontuberculous mycobacteria (NTM) isolation and their related outcomes among pediatric patients of a Brazilian university hospital from 2012 to 2019. NTM were identified in different clinical samples by microbiological culture and molecular-based methods. NTM were isolated from 14 patients, out of whom four (27%) were infected and were treated accordingly. Two were infected with Mycobacterium avium complex (MAC), two with M. abscessus complex (MABSC) and one with M. intracellulare. Two patients had cystic fibrosis-related lung disease and improved after successful NTM eradication. One patient was HIV-positive and died. One patient had severe combined immunodeficiency (SCID)-related pneumonia and is currently being followed-up. We conclude that NTM frequency in our center was low among pediatric patients. Whether this is inherent to Brazilian patients, due to the broad coverage of the Bacille Calmette-Guérin (BCG) vaccine in Brazil, or a result of underdiagnosis remains to be elucidated.
本研究旨在描述 2012 年至 2019 年巴西一家大学医院儿科患者中非结核分枝杆菌（NTM）分离的频率及其相关结果。通过微生物培养和基于分子的方法从不同的临床标本中鉴定出 NTM。从 14 名患者中分离出 NTM，其中 4 名（27%）感染并进行了相应治疗。2 名感染鸟分枝杆菌复合群（MAC），2 名感染脓肿分枝杆菌复合群（MABSC），1 名感染胞内分枝杆菌。2 名患者患有囊性纤维化相关肺病，在成功清除 NTM 后得到改善。1 名患者 HIV 阳性并死亡。1 名患者患有严重联合免疫缺陷（SCID）相关肺炎，目前正在接受随访。我们得出结论，本中心儿科患者中 NTM 的频率较低。这是巴西患者固有的，还是由于巴西卡介苗（BCG）疫苗的广泛覆盖，或者是由于诊断不足，仍有待阐明。
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