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健康成年人从海鲜干货中吸收氟的药代动力学。

Pharmacokinetics of fluoride absorbed from dried seafoods by healthy adults.

作者信息

Hattab F N

机构信息

Department of Cariology, Faculty of Dentistry, Jordan University of Science and Technology, Irbid.

出版信息

Eur J Clin Pharmacol. 1988;34(5):489-93. doi: 10.1007/BF01046707.

DOI:10.1007/BF01046707
PMID:3203709
Abstract

Dried seafoods are a rich source of fluoride (F). The systemic availability of F from seafoods was studied in 3 healthy adults. The plasma concentration and urinary excretion of F for 24 h following the ingestion of 3.87 +/- 0.32 mg F (mean +/- SD) in seafoods were compared with plasma and urine data following oral administration of 3 mg F in aqueous solution. There was a marked reduction and delay in the absorption of F from seafoods. The relative bioavailability of F from seafoods was 40.8 +/- 5.1%. These findings should be taken into consideration when determining the optimum level of daily F intake.

摘要

干海产品是氟化物(F)的丰富来源。在3名健康成年人中研究了海产品中氟的全身可利用性。将摄入3.87±0.32毫克海产品中氟(均值±标准差)后24小时的血浆氟浓度和尿氟排泄量,与口服3毫克水溶液中的氟后的血浆和尿液数据进行了比较。海产品中氟的吸收明显减少且延迟。海产品中氟的相对生物利用度为40.8±5.1%。在确定每日氟摄入的最佳水平时应考虑这些发现。

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PLoS One. 2019 Sep 11;14(9):e0222260. doi: 10.1371/journal.pone.0222260. eCollection 2019.

本文引用的文献

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