Symposium review: Late-gestation maternal factors affecting the health and development of dairy calves.

Efficient production of heifers is fundamental to the productivity and sustainability of dairy farms. However, high preweaning morbidity and mortality rates are frequently reported worldwide, imposing substantial welfare and economic implications. A major contributing factor to disease susceptibility in the neonatal stage is the inability of calves to mount an effective immune response. Appreciation is now greater that exposure in utero to several stresses (nutritional, social, metabolic, and so on) during the last stages of pregnancy have downstream carryover effects in calves' health, growth, and development. Suboptimal intrauterine conditions during critical periods of development lead to changes in tissue structure and function that may have long-term consequences on the offspring's physiology and disease susceptibility. Indeed, preweaning metabolic function and growth are associated with future milk production. Thus, late-gestation carryover effects span into the lactating stage of the heifers. Nevertheless, researchers have been studying how to minimize these effects. This review will discuss the effects of maternal stress during late gestation on the offspring's growth, productivity, metabolism, and health. In addition, strategies focusing on maternal interventions that improve neonatal health will be discussed. A better understanding of the intrauterine conditions affecting calf health and growth may facilitate the design of management practices that could improve neonatal development and future cow productivity.