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[儿童再生障碍性贫血的骨髓移植治疗(作者译)]

[Treatment of aplastic anemia in children by bone marrow transplantation (author's transl)].

作者信息

Wündisch G F

出版信息

Klin Padiatr. 1977 Jan;189(8):50-9.

PMID:320373
Abstract

The course of a successful bone marrow transplantation in a 8 year old boy with severe aplastic anemia is presented. The boy lives now 22 months after bone marrow transplantation with normal bone marrow function and an essentially undisturbed performance; The indication for bone marrow transplantation for severe aplastic anemia in children is discussed. Despite improved intensive supportive care (antibiotics, infectious prophylaxis, substitution of blood components) and the treatment with corticosteroids and/or androgens the mortality of sever aplastic anemia in childhood is still high. The advantages of early bone marrow transplantation in severe cases are stressed.

摘要

本文介绍了一名8岁重型再生障碍性贫血男孩成功进行骨髓移植的过程。该男孩在骨髓移植后已存活22个月,骨髓功能正常,生活基本未受影响;文中讨论了儿童重型再生障碍性贫血进行骨髓移植的指征。尽管强化支持治疗(抗生素、感染预防、血液成分替代)有所改善,以及使用了皮质类固醇和/或雄激素进行治疗,但儿童重型再生障碍性贫血的死亡率仍然很高。文中强调了在严重病例中早期进行骨髓移植的优势。

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