Department of Respiratory Disease, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Traditional Chinese Medicine, Shanghai Public Health Clinical Center, Shanghai, China.
Biosci Trends. 2020 Mar 16;14(1):64-68. doi: 10.5582/bst.2020.01030. Epub 2020 Feb 9.
Pneumonia associated with the 2019 novel coronavirus (2019-nCoV) is continuously and rapidly circulating at present. No effective antiviral treatment has been verified thus far. We report here the clinical characteristics and therapeutic procedure for four patients with mild or severe 2019-nCoV pneumonia admitted to Shanghai Public Health Clinical Center. All the patients were given antiviral treatment including lopinavir/ritonavir (Kaletra), arbidol, and Shufeng Jiedu Capsule (SFJDC, a traditional Chinese medicine) and other necessary support care. After treatment, three patients gained significant improvement in pneumonia associated symptoms, two of whom were confirmed 2019-nCoV negative and discharged, and one of whom was virus negative at the first test. The remaining patient with severe pneumonia had shown signs of improvement by the cutoff date for data collection. Results obtained in the current study may provide clues for treatment of 2019-nCoV pneumonia. The efficacy of antiviral treatment including lopinavir/ritonavir, arbidol, and SFJDC warrants further verification in future study.
目前,与 2019 年新型冠状病毒(2019-nCoV)相关的肺炎持续快速传播。到目前为止,尚未验证有效的抗病毒治疗方法。我们在此报告上海公共卫生临床中心收治的 4 例轻度或重度 2019-nCoV 肺炎患者的临床特征和治疗过程。所有患者均接受抗病毒治疗,包括洛匹那韦/利托那韦(克力芝)、阿比多尔和疏风解毒胶囊(SFJDC,一种中药)以及其他必要的支持性护理。治疗后,3 例患者肺炎相关症状明显改善,其中 2 例患者经检测 2019-nCoV 为阴性并出院,1 例患者首次检测为病毒阴性。截至数据收集截止日期,另一名重症肺炎患者已显示出改善迹象。本研究结果可能为治疗 2019-nCoV 肺炎提供线索。洛匹那韦/利托那韦、阿比多尔和 SFJDC 的抗病毒治疗效果需要在未来的研究中进一步验证。