Department of Gastroenterology, Faculty of Medicine, Çukurova University, Adana, Turkey.
J Gene Med. 2020 Jun;22(6):e3172. doi: 10.1002/jgm.3172. Epub 2020 Mar 2.
Hepatitis B virus (HBV) infection causes liver failure, liver cirrhosis and hepatocellular carcinoma. The FOXP3 gene polymorphisms, the rs2232365 A/G and the rs3761548 A/C, were identified to be associated with regulatory T cell-mediated immunosuppression. The response to HBV infection may be affected by FOXP3 polymorphisms. The present study aimed to assess the relationship between FOXP3 gene polymorphisms and chronic HBV infection risk.
FOXP3 gene polymorphisms were explored in 237 chronic HBV patients and in 237 individuals with HBV spontaneous clearance using a real-time polymerase chain reaction.
The patients with rs2232365 AG and rs3761548 AC genotype had a 1.20- and a 1.58-fold greater HBV risk than non-carriers patients, although they were not significant. Moreover, the AA genotypes of both polymorphisms in the males and females had an increased the persistent HBV risk, although this also was not statistically significant.
In conclusion, the present study is the first report to demonstrate that these polymorphisms have no effect on the risk of chronic HBV infection. This results suggest that FOXP3 gene polymorphisms and FOXP3 expression should be evaluated together with frequency of regulatory T cells in HBV infection.
乙型肝炎病毒（HBV）感染可导致肝功能衰竭、肝硬化和肝细胞癌。FOXP3 基因多态性，如 rs2232365A/G 和 rs3761548A/C，与调节性 T 细胞介导的免疫抑制有关。FOXP3 多态性可能影响对 HBV 感染的反应。本研究旨在评估 FOXP3 基因多态性与慢性 HBV 感染风险之间的关系。
采用实时聚合酶链反应检测 237 例慢性 HBV 患者和 237 例 HBV 自发清除患者的 FOXP3 基因多态性。
与非携带者相比，rs2232365AG 和 rs3761548AC 基因型患者的 HBV 风险分别增加了 1.20 倍和 1.58 倍，但差异无统计学意义。此外，两种多态性的 AA 基因型在男性和女性中均增加了持续性 HBV 感染的风险，但差异无统计学意义。
综上所述，本研究首次表明这些多态性对慢性 HBV 感染风险没有影响。这表明 FOXP3 基因多态性和 FOXP3 表达应与 HBV 感染中调节性 T 细胞的频率一起进行评估。
