Zhao Dan, Li Yue-Heng, Yang Zheng-Yan, Cai Ting, Wu Xiao-Yan, Xia Yu, Zhou Zhi
Dept. of Preventive Stomatology, Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Muni-cipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401120, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2020 Feb 1;38(1):59-68. doi: 10.7518/hxkq.2020.01.011.
To systematically evaluate the repairing effect of stem cells on facial nerve defects.
Articles regarding the regenerating effect of stem cells on facial nerves in animals were collected from the databases of Pubmed, Cochrane Library, Web of Science, Embase, Scopus, and CBM. Two professionals independently completed the article screening, data extraction, and bias risk assessment. RevMan 5.3 and random-effects models were used for the statistical analysis, and the results were presented in the form of mean differences (MD) with a 95%CI. The results of functional evaluation (vibrissae movement, facial paralysis) and histological evaluation (density of myelinated fibers, diameter of fibers, thickness of myelin sheath, G ratio) of facial nerve were Meta-analyzed.
A total of 4 614 articles were retrieved from the 6 databases, and 15 of these articles were included in the Meta-analysis. For vibrissae movement and facial paralysis, the stem cell group scored significantly higher than the non-stem cell group (P<0.05). The density of myelinated fibers and thickness of the myelin sheath in the stem cell group were higher than those in the non-stem cell group (P<0.05). The G ratio in the stem cell group was smaller than that in the non-stem cell group (P=0.001). There was no significant difference in fiber diameter (P=0.08).
Stem cells have potential in promoting facial nerve regeneration.
系统评价干细胞对面神经缺损的修复效果。
从Pubmed、Cochrane图书馆、Web of Science、Embase、Scopus和CBM数据库中收集有关干细胞对动物面神经再生作用的文章。两名专业人员独立完成文章筛选、数据提取和偏倚风险评估。采用RevMan 5.3和随机效应模型进行统计分析，结果以均数差（MD）及95%可信区间（CI）的形式呈现。对面神经功能评价（触须运动、面瘫）和组织学评价（有髓纤维密度、纤维直径、髓鞘厚度、G比值）的结果进行Meta分析。
从6个数据库中共检索到4614篇文章，其中15篇文章纳入Meta分析。在触须运动和面瘫方面，干细胞组得分显著高于非干细胞组（P<0.05）。干细胞组有髓纤维密度和髓鞘厚度高于非干细胞组（P<0.05）。干细胞组的G比值小于非干细胞组（P=0.001）。纤维直径差异无统计学意义（P=0.08）。
干细胞在促进面神经再生方面具有潜力。
