El Hoshy Khaled, Abdel-Halim Mona R E, El-Nabarawy Eman, Shalaby Suzan
Drs. El Hoshy, Abdel-Halim, El-Nabarawy, and Shalaby are with the Dermatology Department at Cairo University in Cairo, Egypt.
J Clin Aesthet Dermatol. 2019 Dec;12(12):13-16. Epub 2019 Dec 1.
A 77-year-old female patient presented with bilateral tender, swollen, erythematous, focally crusted cheeks with a discharge of pus and necrotic material, which had developed one month after autologous fat transfer and a corrective injection procedure conducted to correct an overdone fat transfer. Histopathological examination of the discharged material using routine hematoxylin and eosin staining revealed degenerated collagen admixed with three different filler materials. Scattered all throughout the specimen were numerous thick-walled, basophilic, nonbudding spherical bodies of variable sizes. The bodies stained positively with Periodic acid-Schiff and Alcian blue and showed internal septation and sporangia with a morula-like appearance. The morphology of these bodies was characteristic of a infection. The patient was treated by surgical drainage accompanied by itraconazole 200mg daily for six months, ultimately showing marked improvement.
一名77岁女性患者双侧脸颊出现压痛、肿胀、红斑，局部结痂，有脓液和坏死物质排出，这是在自体脂肪移植及为纠正过度脂肪移植而进行的矫正注射手术后一个月出现的。对排出物进行常规苏木精和伊红染色的组织病理学检查显示，退变的胶原与三种不同的填充材料混合在一起。在整个标本中散在着许多大小不一的厚壁、嗜碱性、无芽球形小体。这些小体经高碘酸-希夫染色和阿尔辛蓝染色呈阳性，显示内部有分隔以及呈桑椹样外观的孢子囊。这些小体的形态具有 感染的特征。患者接受了手术引流，并每日服用200mg伊曲康唑，持续六个月，最终病情显著改善。 （注：原文中“a infection”此处应有具体感染名称未给出）
