Lee Jong-Chan, Shin In-Sik, Kim Gang-Hyeon, Park Na-Hyeong, Moon Chang-Jong, Bae Chun-Sik, Kang Sung-Soo, Kim Sung-Ho, Shin Dong-Ho, Kim Jong-Choon
Animal Medical Center, College of Veterinary Medicine, Chonnam National University, Gwangju, 500-757 Korea.
Toxicol Res. 2008 Dec;24(4):307-314. doi: 10.5487/TR.2008.24.4.307. Epub 2008 Dec 1.
The present study was carried out to investigate the potential adverse effects of 1,3-dichloro-2-propanol on pregnant dams after maternal exposure during the gestational days (GD) 6 through 19 in Sprague-Dawley rats. The tested chemical was administered orally to pregnant rats at dose levels of 0, 10, 30, or 90 mg/kg/day. During the test period, clinical signs, mortality, body weights, food consumption, serum biochemistry, gross findings, organ weights, and Caesarean section findings were examined. In the 90 mg/kg group, decreases in the body weight gain and food consumption, and increases in the weights of liver and adrenal glands were observed. Serum biochemical investigations revealed increases in aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholesterol (CHO), triglyceride (TG), alkaline phosphatase (ALP), and bilirubin (BIL) and decreases in glucose (GLU), albumin (ALB) and total protein (TP). In the 30 mg/kg group, a decrease in the food consumption and an increase in the liver weight were observed. Serum biochemical investigation also showed increases in CHO and TG and a decrease in glucose. Since there were no signs of maternal toxicity in the 10 mg/kg group, it is considered to be the no-observed-adverse-effect level (NOAEL) of 1,3-dichloro-2-propanol. It is concluded that successive oral administration of 1,3-dichloro-2-propanol to pregnant rats for 14 days may cause significant toxicities in body weight and liver at a dose rate ≥ 30 mg/kg/day.
本研究旨在调查1,3 - 二氯 - 2 - 丙醇在妊娠第6至19天经母体暴露后对Sprague - Dawley大鼠孕鼠的潜在不良影响。将受试化学品以0、10、30或90 mg/kg/天的剂量水平经口给予孕鼠。在试验期间，检查了临床体征、死亡率、体重、食物消耗量、血清生化指标、大体检查结果、器官重量和剖腹产检查结果。在90 mg/kg组中，观察到体重增加和食物消耗量减少，肝脏和肾上腺重量增加。血清生化检查显示天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、胆固醇（CHO）、甘油三酯（TG）、碱性磷酸酶（ALP）和胆红素（BIL）升高，葡萄糖（GLU）、白蛋白（ALB）和总蛋白（TP）降低。在30 mg/kg组中，观察到食物消耗量减少和肝脏重量增加。血清生化检查还显示CHO和TG升高，葡萄糖降低。由于10 mg/kg组未出现母体毒性迹象，因此认为该剂量为1,3 - 二氯 - 2 - 丙醇的无观察到有害作用水平（NOAEL）。得出的结论是，连续14天对孕鼠经口给予1,3 - 二氯 - 2 - 丙醇，剂量≥30 mg/kg/天时可能会对体重和肝脏产生显著毒性。
