Nefedov M D, Gar'kavtseva R F, Trubnikov V I
Genetika. 1988 Aug;24(8):1456-61.
The multifactorial nature of breast cancer was established based on population and family study, the contribution of genetic factors being 52% (premenopausal--62 and postmenopausal--39%). Genetic heterogeneity of different coefficients of inheritance of breast cancer with the portion of common genes was shown to be 53%. The analysis of breast cancer interaction with other malignant neoplasms revealed that the development of other malignant neoplasms was the result of the influence of partially common genes. On the basis of data obtained in this study, the tables of repeated risk for the relatives have been worked out which may be used for medico-genetic consultations.
乳腺癌的多因素性质是基于人群和家族研究确定的，遗传因素的贡献率为52%（绝经前为62%，绝经后为39%）。乳腺癌不同遗传系数与常见基因部分的遗传异质性显示为53%。对乳腺癌与其他恶性肿瘤相互作用的分析表明，其他恶性肿瘤的发生是部分常见基因影响的结果。根据本研究获得的数据，已制定出亲属复发风险表，可用于医学遗传咨询。
