非甾体抗炎药（NSAIDs）的全身应用：肾衰竭风险
Non-steroidal Anti-inflammatory Drugs (NSAIDs) Systemic Use: The Risk of Renal Failure.
作者信息
Bensman Albert
机构信息
Service de Nephrologie Pediatrique, Hopital Necker-Enfants Malades, Paris, France.
出版信息
Front Pediatr. 2020 Jan 24;7:517. doi: 10.3389/fped.2019.00517. eCollection 2019.
Abstract
For the pediatric nephrologist, the over-the-counter status for non-steroidal anti-inflammatory drugs (NSAIDs) is surprising due to their possible harmful side effects. These can include acute renal failure due mainly to glomerular hypoperfusion which may lead to acute tubular necrosis; more rarely in children, medullary ischemic injury and cardiovascular diseases; acute or chronic interstitial nephritis which may cause chronic renal failure. All of them may create electrolyte abnormalities: hyponatremia, hyperkaliemia, renal tubular acidosis, fluid retention causing hypertension.
摘要
对于儿科肾脏病专家而言，非甾体类抗炎药（NSAIDs）的非处方状态令人惊讶，因为它们可能具有有害的副作用。这些副作用包括主要由于肾小球灌注不足导致的急性肾衰竭，这可能会引发急性肾小管坏死；在儿童中较为罕见的髓质缺血性损伤和心血管疾病；可能导致慢性肾衰竭的急性或慢性间质性肾炎。所有这些都可能导致电解质异常：低钠血症、高钾血症、肾小管酸中毒、导致高血压的液体潴留。
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