• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The enduring promise of phosphodiesterase 5 inhibitors for colon cancer prevention.

作者信息

Browning Darren D

机构信息

Department of Biochemistry and Molecular Biology, Medical College of Georgia at Augusta University, Augusta, GA, USA.

出版信息

Transl Gastroenterol Hepatol. 2019 Dec 23;4:83. doi: 10.21037/tgh.2019.12.10. eCollection 2019.

DOI:10.21037/tgh.2019.12.10
PMID:32039288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6987326/
Abstract
摘要

相似文献

1
The enduring promise of phosphodiesterase 5 inhibitors for colon cancer prevention.磷酸二酯酶5抑制剂在预防结肠癌方面的持久前景。
Transl Gastroenterol Hepatol. 2019 Dec 23;4:83. doi: 10.21037/tgh.2019.12.10. eCollection 2019.
2
Phosphodiesterase-5 inhibitors for colon cancer chemoprevention.用于结肠癌化学预防的磷酸二酯酶-5抑制剂。
Aging (Albany NY). 2018 Sep 5;10(9):2216-2217. doi: 10.18632/aging.101545.
3
Therapeutic opportunities in colon cancer: Focus on phosphodiesterase inhibitors.结肠癌的治疗机会：聚焦磷酸二酯酶抑制剂。
Life Sci. 2019 Aug 1;230:150-161. doi: 10.1016/j.lfs.2019.05.043. Epub 2019 May 21.
4
The impact of treatment choice for localized prostate cancer on response to phosphodiesterase inhibitors.局限性前列腺癌治疗选择对磷酸二酯酶抑制剂反应的影响
J Urol. 2008 Mar;179(3):1072-6; discussion 1076. doi: 10.1016/j.juro.2007.10.053. Epub 2008 Jan 18.
5
Prevention by phosphodiesterase inhibitors of antigen-induced contraction of guinea-pig colonic smooth muscle.磷酸二酯酶抑制剂对豚鼠结肠平滑肌抗原诱导收缩的预防作用。
Br J Pharmacol. 1994 Jan;111(1):259-63. doi: 10.1111/j.1476-5381.1994.tb14053.x.
6
Roflumilast, type 4 phosphodiesterase inhibitor, attenuates inflammation in rats with ulcerative colitis via down-regulation of iNOS and elevation of cAMP.罗氟司特，一种 4 型磷酸二酯酶抑制剂，通过下调 iNOS 和升高 cAMP 来减轻溃疡性结肠炎大鼠的炎症。
Int Immunopharmacol. 2018 Mar;56:36-42. doi: 10.1016/j.intimp.2018.01.004. Epub 2018 Jan 10.
7
Reevaluating the role of phosphodiesterase inhibitors in the treatment of cardiovascular disease.重新评估磷酸二酯酶抑制剂在心血管疾病治疗中的作用。
Clin Cardiol. 2002 Jun;25(6):256-62. doi: 10.1002/clc.4960250603.
8
Studies on the phosphodiesterase in various organs of rats and guinea-pigs of different ages and different sex.
Acta Physiol Pharmacol Bulg. 1977;3(1):38-45.
9
Effect of phosphodiesterase inhibitors in the bladder.磷酸二酯酶抑制剂对膀胱的作用。
Asian J Urol. 2015 Jan;2(1):33-37. doi: 10.1016/j.ajur.2015.04.014. Epub 2015 Apr 16.
10
Prevention of contrast medium-induced renal vasospasm by phosphodiesterase inhibition.
Invest Radiol. 1998 Dec;33(12):858-62. doi: 10.1097/00004424-199812000-00003.

引用本文的文献

1
A Non-Systemic Phosphodiesterase-5 Inhibitor Suppresses Colon Proliferation in Mice.一种非系统性磷酸二酯酶-5 抑制剂可抑制小鼠结肠增殖。
Int J Mol Sci. 2023 May 28;24(11):9397. doi: 10.3390/ijms24119397.
2
Inhibition of Colon Cancer Cell Growth by Phosphodiesterase Inhibitors Is Independent of cGMP Signaling.磷酸二酯酶抑制剂抑制结肠癌细胞生长不依赖于 cGMP 信号通路。
J Pharmacol Exp Ther. 2022 Apr;381(1):42-53. doi: 10.1124/jpet.121.001075. Epub 2022 Feb 2.
3
How do phosphodiesterase-5 inhibitors affect cancer? A focus on glioblastoma multiforme.磷酸二酯酶-5抑制剂如何影响癌症？聚焦多形性胶质母细胞瘤。
Pharmacol Rep. 2022 Apr;74(2):323-339. doi: 10.1007/s43440-021-00349-6. Epub 2022 Jan 20.
4
Pros and Cons of Pharmacological Manipulation of cGMP-PDEs in the Prevention and Treatment of Breast Cancer.环磷酸鸟苷磷酸二酯酶在预防和治疗乳腺癌中的药理学干预的利弊。
Int J Mol Sci. 2021 Dec 27;23(1):262. doi: 10.3390/ijms23010262.
5
An update on guanylyl cyclase C in the diagnosis, chemoprevention, and treatment of colorectal cancer.关于鸟苷酸环化酶 C 在结直肠癌的诊断、化学预防和治疗中的最新进展。
Expert Rev Clin Pharmacol. 2020 Oct;13(10):1125-1137. doi: 10.1080/17512433.2020.1826304. Epub 2020 Oct 6.

本文引用的文献

1
Effects of Family History on Relative and Absolute Risks for Colorectal Cancer: A Systematic Review and Meta-Analysis.家族史对结直肠癌相对风险和绝对风险的影响：系统评价和荟萃分析。
Clin Gastroenterol Hepatol. 2019 Dec;17(13):2657-2667.e9. doi: 10.1016/j.cgh.2019.09.007. Epub 2019 Sep 13.
2
Use of Phosphodiesterase 5 Inhibitors Is Associated With Lower Risk of Colorectal Cancer in Men With Benign Colorectal Neoplasms.使用磷酸二酯酶 5 抑制剂与良性结直肠肿瘤男性的结直肠癌风险降低相关。
Gastroenterology. 2019 Sep;157(3):672-681.e4. doi: 10.1053/j.gastro.2019.05.012. Epub 2019 May 16.
3
Update in Surveillance Recommendations in Individuals With Conventional Adenomas.传统腺瘤患者监测建议的更新
Curr Treat Options Gastroenterol. 2019 Jun;17(2):303-312. doi: 10.1007/s11938-019-00235-4.
4
Barriers to Colonoscopy in an Uninsured Patient Population-A Quality Improvement Project.
Am Surg. 2019 Jan 1;85(1):111-114.
5
Magnitude, Risk Factors, and Factors Associated With Adenoma Miss Rate of Tandem Colonoscopy: A Systematic Review and Meta-analysis.结肠镜检查中腺瘤漏诊率的大小、危险因素及相关因素：系统评价和荟萃分析。
Gastroenterology. 2019 May;156(6):1661-1674.e11. doi: 10.1053/j.gastro.2019.01.260. Epub 2019 Feb 6.
6
Efficacy and Tolerability of Guanylate Cyclase-C Agonists for Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation: A Systematic Review and Meta-Analysis.鸟苷酸环化酶 C 激动剂治疗便秘型肠易激综合征和慢性特发性便秘的疗效和耐受性：系统评价和荟萃分析。
Am J Gastroenterol. 2018 Mar;113(3):329-338. doi: 10.1038/ajg.2017.495. Epub 2018 Jan 30.
7
Cyclic-GMP-Elevating Agents Suppress Polyposis in mice by Targeting the Preneoplastic Epithelium.环鸟苷酸升高剂通过靶向癌前上皮抑制 小鼠的息肉形成。
Cancer Prev Res (Phila). 2018 Feb;11(2):81-92. doi: 10.1158/1940-6207.CAPR-17-0267. Epub 2018 Jan 4.
8
Meta-Analysis of the Association Between Phosphodiesterase Inhibitors (PDE5Is) and Risk of Melanoma.磷酸二酯酶抑制剂（PDE5Is）与黑色素瘤风险关联的Meta分析
J Natl Cancer Inst. 2017 Aug 1;109(8). doi: 10.1093/jnci/djx086.
9
Effects of chemopreventive agents on the incidence of recurrent colorectal adenomas: a systematic review with network meta-analysis of randomized controlled trials.化学预防剂对复发性结肠直肠腺瘤发病率的影响：一项对随机对照试验的网络荟萃分析的系统评价
Onco Targets Ther. 2017 May 23;10:2689-2700. doi: 10.2147/OTT.S127335. eCollection 2017.
10
Sildenafil Suppresses Inflammation-Driven Colorectal Cancer in Mice.西地那非可抑制小鼠炎症驱动的结直肠癌。
Cancer Prev Res (Phila). 2017 Jul;10(7):377-388. doi: 10.1158/1940-6207.CAPR-17-0015. Epub 2017 May 3.