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神经原性穴位的配对机械和电刺激诱导阿片介导的降压作用在大鼠中。

Paired mechanical and electrical acupuncture of neurogenic spots induces opioid-mediated suppression of hypertension in rats.

机构信息

Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, 42158, South Korea.

Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, 34054, South Korea.

出版信息

J Physiol Sci. 2020 Feb 6;70(1):14. doi: 10.1186/s12576-020-00735-4.

DOI:10.1186/s12576-020-00735-4
PMID:32039692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7005077/
Abstract

While our recent studies have suggested that effective acupoints display neurogenic inflammation and can be identified as neurogenic spots (Neuro-Sps), the optimal stimulation conditions and the underlying mechanisms remain uncharacterized. We developed a combined mechano-electrical acupuncture device (MEA) and examined the effects of acupuncture at Neuro-Sps on systolic blood pressure (BP) in a rat model of immobilization-induced hypertension (IMH) and the mediation of endogenous opioid systems in its effect. Cutaneous neurogenic spots were found mostly in the forelimb. Electrical and mechanical acupuncture of Neuro-Sps increased 22-kHz ultrasonic vocalizations (USVs), c-Fos expression and cell excitability in the midbrain and synergistically alleviated the development of hypertension following immobilization stress, which was prevented by administration of the opioid antagonist naloxone into the rostral ventrolateral medulla (rVLM). These findings suggest that mechanical and electrical stimulation at Neuro-Sps suppresses the development of hypertension via mediation of the endogenous opioid system.

摘要

虽然我们最近的研究表明，有效的穴位会表现出神经源性炎症，可以被识别为神经源性点（Neuro-Sps），但最佳的刺激条件和潜在的机制仍未被描述。我们开发了一种组合的机械电针灸设备（MEA），并检查了在固定应激诱导的高血压（IMH）大鼠模型中，Neuro-Sps 针灸对收缩压（BP）的影响，以及内源性阿片系统在其作用中的介导作用。皮肤神经源性点主要在前肢发现。Neuro-Sps 的电和机械针灸增加了 22 kHz 超声波发声（USVs）、中脑的 c-Fos 表达和细胞兴奋性，并协同缓解了固定应激后高血压的发展，而将阿片拮抗剂纳洛酮注入延髓腹外侧区（rVLM）则阻止了这种发展。这些发现表明，Neuro-Sps 的机械和电刺激通过内源性阿片系统的介导抑制了高血压的发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45cb/10716999/934c6977905e/12576_2020_735_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45cb/10716999/1a30ce979603/12576_2020_735_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45cb/10716999/45f940d0d4bb/12576_2020_735_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45cb/10716999/6ccc41a771ca/12576_2020_735_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45cb/10716999/934c6977905e/12576_2020_735_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45cb/10716999/1a30ce979603/12576_2020_735_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45cb/10716999/45f940d0d4bb/12576_2020_735_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45cb/10716999/6ccc41a771ca/12576_2020_735_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45cb/10716999/934c6977905e/12576_2020_735_Fig4_HTML.jpg

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