Kambic H, Sutton C, Oku T, Sugita Y, Murabayashi S, Harasaki H, Kasick J, Shirey E, Nosé Y
Department of Artificial Organs, Cleveland Clinic Foundation, Ohio.
Int J Artif Organs. 1988 Nov;11(6):487-92.
A method was developed for the noninvasive insertion of a vascular ring prostheses aimed at preserving arterial patency and preventing restenosis following angioplasty. Using a specially designed 7F catheter 22 nitinol (TiNi) wire prostheses (I.D. 5 mm; 0.25 mm thickness) were torsion reduced in diameter and inserted under fluoroscopy into both carotid (n = 2) and iliac-femoral arteries (n = 20) of dogs. Aspirin (650 mg BID) and Persantin (200 mg BID) were given for only 30 days postoperatively. Angiography of all rings at 1, 6, 12 months exhibited excellent biocompatibility and long term patency 91% (20/22) as reported in Trans ASAIO 32:30, 1986. Four rings inserted in the right and left common iliac arteries and femoral artery were followed for up to 2 years and exhibited 100% patency. Angiography demonstrated that the anchorage of the prostheses was stable and the lumen was uniformly covered by a thin neointimal layer of endothelial like cells. The prostheses were patent with no evidence of thrombosis or inflammation. In view of the problem of recurrent stenosis occurring during the healing period after balloon angioplasty (PTA or PTCA), this approach may lead to a new means of clinical intervention in atherosclerosis.
开发了一种用于无创插入血管环假体的方法，旨在保持动脉通畅并防止血管成形术后再狭窄。使用专门设计的7F导管，将22个镍钛诺（TiNi）丝假体（内径5mm；厚度0.25mm）在直径上进行扭减，然后在荧光透视下插入犬的双侧颈动脉（n = 2）和髂股动脉（n = 20）。阿司匹林（650mg，每日两次）和潘生丁（200mg，每日两次）仅在术后30天给予。如1986年《美国人工器官学会会刊》第32卷第30页所报道，所有环在1、6、12个月时的血管造影显示出优异的生物相容性和91%（20/22）的长期通畅率。插入左右髂总动脉和股动脉的4个环随访长达2年，通畅率为100%。血管造影显示假体的固定稳定，管腔被一层薄的内皮样细胞新内膜层均匀覆盖。假体通畅，无血栓形成或炎症迹象。鉴于球囊血管成形术（PTA或PTCA）后愈合期出现的再狭窄问题，这种方法可能会导致一种新的动脉粥样硬化临床干预手段。
