Carrig C B, Sponenberg D P, Schmidt G M, Tvedten H W
Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg 24061.
J Am Vet Med Assoc. 1988 Nov 15;193(10):1269-72.
A breeding colony was established to investigate the inheritance of associated ocular and skeletal dysplasia in Labrador Retrievers; 124 pups were produced. These pups were evaluated for the presence of ocular lesions, including cataracts, vitreous strands, persistent hyaloid remnants, retinal folds, retinal dysplasia, peripapillary hyperreflectivity, and rhegmatogenous retinal detachments, and skeletal abnormality, which was recognized by shorter than normal forelimbs and an abnormal morphologic appearance of the radius and ulna. Analysis of the distribution of lesions in pups indicated that the syndrome is caused by one abnormal gene, which has recessive effects on the skeleton and incompletely dominant effects on the eye. This would suggest that suspect carrier dogs could be identified by test matings with a known homozygote.
为了研究拉布拉多寻回犬相关眼部和骨骼发育异常的遗传情况，建立了一个繁殖群体；共繁育出124只幼犬。对这些幼犬进行了眼部病变检查，包括白内障、玻璃体条索、永存玻璃体残余、视网膜皱褶、视网膜发育异常、视乳头周围高反射性和孔源性视网膜脱离，以及骨骼异常检查，骨骼异常表现为前肢比正常短以及桡骨和尺骨形态异常。对幼犬病变分布的分析表明，该综合征由一个异常基因引起，该基因对骨骼有隐性影响，对眼睛有不完全显性影响。这表明可以通过与已知纯合子进行测试交配来识别疑似携带犬。
