Winter temperature and myocardial infarction in Brisbane, Australia: Spatial and temporal analyses.

Myocardial infarction (MI) incidence often peaks in winter, but it remains unclear how winter temperature affects MI temporally and spatially. We examined the short-term effects of winter temperature on the risk of MI and explored spatial associations of winter MI hospitalizations with temperature and socioeconomic status (area-based index) in Brisbane, Australia. We used a distributed lag non-linear model to fit the association at the city level between population-weighted daily mean temperature and daily MI hospitalizations during 11 winters of 2005-2015. For each winter, a Bayesian spatial conditional autoregressive model was fitted to examine the associations at postal code level of MI hospitalisations with temperature and socioeconomic status measured as the Index of Relative Socio-Economic Advantage and Disadvantage (IRSAD). Area-specific winter temperature was categorised into three levels: cold (<25th percentile of average winter temperature across postal areas), mild (25th-75th percentile) and warm (>75th percentile). This study included 4978 MI hospitalizations. At the city level, each 1 °C drop in temperature below a threshold of 15.6 °C was associated with a relative risk (RR) of 1.016 (95% confidence interval (CI): 1.008-1.024) for MI hospitalizations on the same day. Low temperature had a much delayed and transient effect on women but an immediate and longer-lasting effect on men. Winter MI incidence rate varied spatially in Brisbane, with a higher incidence rate in warmer areas (RR for mild areas: 1.214, 95%CI: 1.116-1.320; RR for warm areas: 1.251, 95%CI: 1.127-1.389; cold areas as the reference) and in areas with lower socioeconomic levels (RR: 0.900, 95%CI: 0.886-0.914 for each decile increase in IRSAD). This study provides compelling evidence that short-term winter temperature drops were associated with an elevated risk of MI in the subtropical region with a mild winter. Particular attention also needs to be paid to people living in relatively warm and socioeconomically disadvantaged communities in winter.