Wright J R, Lacy P E
Department of Pathology, Washington University School of Medicine, St Louis, MO 63110.
J Comp Pathol. 1988 Nov;99(4):449-54. doi: 10.1016/0021-9975(88)90063-1.
Spontaneous hydronephrosis was observed in 15 of 33 necropsied C57BL/KsJ mice. The gross and histological appearances of these lesions are described. Spontaneous hydronephrosis is rare in mice and has not been previously described in this strain. At least four different mutations are reported to cause hydronephrosis in the mouse; each is associated with a high incidence of severe skeletal defects. Because no skeletal malformations were observed in the present study, it is likely that either a multigenic trait which has been present for a long time but is expressed variably, or a mutation other than those previously described may be responsible for hydronephrosis in C57BL/KsJ mice.
在33只接受尸检的C57BL/KsJ小鼠中，有15只观察到自发性肾积水。本文描述了这些病变的大体和组织学表现。自发性肾积水在小鼠中较为罕见，此前在该品系中尚未有过相关报道。据报道，至少有四种不同的突变可导致小鼠肾积水；每种突变都与严重骨骼缺陷的高发生率相关。由于在本研究中未观察到骨骼畸形，因此C57BL/KsJ小鼠的肾积水可能是由长期存在但表达可变的多基因性状，或者是先前未描述过的突变引起的。
