髓鞘退化和髓鞘更新减少导致与年龄相关的记忆缺陷。
Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory.
机构信息
Department of Histology and Embryology, Chongqing Key Laboratory of Neurobiology, Brain and Intelligence Research Key Laboratory of Chongqing Education Commission, Third Military Medical University, Chongqing, China.
Department of Neurology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
出版信息
Nat Neurosci. 2020 Apr;23(4):481-486. doi: 10.1038/s41593-020-0588-8. Epub 2020 Feb 10.
Cognitive decline remains an unaddressed problem for the elderly. We show that myelination is highly active in young mice and greatly inhibited in aged mice, coinciding with spatial memory deficits. Inhibiting myelination by deletion of Olig2 in oligodendrocyte precursor cells impairs spatial memory in young mice, while enhancing myelination by deleting the muscarinic acetylcholine receptor 1 in oligodendrocyte precursor cells, or promoting oligodendroglial differentiation and myelination via clemastine treatment, rescues spatial memory decline during aging.
认知能力衰退仍是老年人面临的一个未解决的问题。我们发现，髓鞘形成在年轻小鼠中非常活跃，而在老年小鼠中则受到极大抑制，这与空间记忆缺陷相一致。通过在少突胶质前体细胞中删除 Olig2 来抑制髓鞘形成会损害年轻小鼠的空间记忆，而通过在少突胶质前体细胞中删除毒蕈碱乙酰胆碱受体 1 或通过克他命治疗来促进少突胶质细胞分化和髓鞘形成，则可以挽救衰老过程中的空间记忆衰退。
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