胆汁淤积性肝病的预防性护理：给专科医生和亚专科医生的经验之谈
Preventative care in cholestatic liver disease: Pearls for the specialist and subspecialist.
作者信息
Malik Adnan, Kardashian Ani A, Zakharia Kais, Bowlus Christopher L, Tabibian James H
机构信息
Department of Public Health and Business Administration, The University of Alabama at Birmingham, Birmingham, AL, USA.
Department of Internal Medicine, Beaumont Hospital, Dearborn, MI, USA.
出版信息
Liver Res. 2019 Jun;3(2):118-127. doi: 10.1016/j.livres.2019.04.001. Epub 2019 May 27.
Cholestatic liver diseases (CLDs) encompass a variety of disorders of abnormal bile formation and/or flow. CLDs often lead to progressive hepatic insult and injury and following the development of cirrhosis and associated complications. Many such complications are clinically silent until they manifest with severe sequelae, including but not limited to life-altering symptoms, metabolic disturbances, cirrhosis, and hepatobiliary diseases as well as other malignancies. Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are the most common CLDs, and both relate to mutual as well as unique complications. This review provides an overview of PSC and PBC, with a focus on preventive measures aimed to reduce the incidence and severity of disease-related complications.
胆汁淤积性肝病（CLD）包括各种胆汁形成异常和/或胆汁流动异常的病症。CLD常导致进行性肝损伤，随后发展为肝硬化及相关并发症。许多此类并发症在出现严重后遗症之前临床上并无症状，这些后遗症包括但不限于改变生活的症状、代谢紊乱、肝硬化、肝胆疾病以及其他恶性肿瘤。原发性硬化性胆管炎（PSC）和原发性胆汁性胆管炎（PBC）是最常见的CLD，二者都有共同的以及独特的并发症。本综述概述了PSC和PBC，重点关注旨在降低疾病相关并发症发生率和严重程度的预防措施。
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