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2
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本文引用的文献

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Monitoring Ceftazidime-Avibactam and Aztreonam Concentrations in the Treatment of a Bloodstream Infection Caused by a Multidrug-Resistant Enterobacter sp. Carrying Both Klebsiella pneumoniae Carbapenemase-4 and New Delhi Metallo-β-Lactamase-1.监测头孢他啶-阿维巴坦和氨曲南在治疗一株携带肺炎克雷伯菌碳青霉烯酶 4 型和新德里金属β-内酰胺酶 1 型的多药耐药肠杆菌引起的血流感染中的浓度。
Clin Infect Dis. 2020 Aug 14;71(4):1095-1098. doi: 10.1093/cid/ciz1155.
2
Risk factors and epidemiologic predictors of blood stream infections with New Delhi Metallo-b-lactamase (NDM-1) producing Enterobacteriaceae.产新德里金属β-内酰胺酶（NDM-1）肠杆菌科血流感染的危险因素和流行病学预测因素。
Epidemiol Infect. 2019 Jan;147:e137. doi: 10.1017/S0950268819000256.
3
NDM Metallo-β-Lactamases and Their Bacterial Producers in Health Care Settings.在医疗环境中 NDM 型金属β-内酰胺酶及其细菌生产者
Clin Microbiol Rev. 2019 Jan 30;32(2). doi: 10.1128/CMR.00115-18. Print 2019 Mar 20.
4
Clinical outcomes after combination treatment with ceftazidime/avibactam and aztreonam for NDM-1/OXA-48/CTX-M-15-producing Klebsiella pneumoniae infection.头孢他啶/阿维巴坦与氨曲南联合治疗产NDM-1/OXA-48/CTX-M-15肺炎克雷伯菌感染后的临床结局
J Antimicrob Chemother. 2018 Apr 1;73(4):1104-1106. doi: 10.1093/jac/dkx496.
5
Co-production of NDM-1 and OXA-232 by ST16 Klebsiella pneumoniae, Italy, 2016.2016年，意大利，ST16型肺炎克雷伯菌同时产生NDM-1和OXA-232。
Future Microbiol. 2017 Oct;12:1119-1122. doi: 10.2217/fmb-2017-0041. Epub 2017 Sep 6.
6
New Delhi Metallo-Beta-Lactamase (NDM-1)-Producing Klebsiella Pneumoniae Isolated from a Burned Patient.从一名烧伤患者身上分离出的产新德里金属β-内酰胺酶（NDM-1）的肺炎克雷伯菌。
Am J Case Rep. 2017 Jul 18;18:805-809. doi: 10.12659/ajcr.903992.
7
Ceftazidime-Avibactam and Aztreonam, an Interesting Strategy To Overcome β-Lactam Resistance Conferred by Metallo-β-Lactamases in Enterobacteriaceae and Pseudomonas aeruginosa.头孢他啶-阿维巴坦与氨曲南：克服肠杆菌科细菌和铜绿假单胞菌中金属β-内酰胺酶介导的β-内酰胺耐药性的有趣策略
Antimicrob Agents Chemother. 2017 Aug 24;61(9). doi: 10.1128/AAC.01008-17. Print 2017 Sep.
8
Can Ceftazidime-Avibactam and Aztreonam Overcome β-Lactam Resistance Conferred by Metallo-β-Lactamases in Enterobacteriaceae?头孢他啶-阿维巴坦和氨曲南能否克服肠杆菌科细菌中金属β-内酰胺酶介导的β-内酰胺耐药性？
Antimicrob Agents Chemother. 2017 Mar 24;61(4). doi: 10.1128/AAC.02243-16. Print 2017 Apr.
9
Spotlight on ceftazidime/avibactam: a new option for MDR Gram-negative infections.头孢他啶/阿维巴坦聚焦：耐多药革兰氏阴性菌感染的新选择。
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10
Performance of the BD MAX™ instrument with Check-Direct CPE real-time PCR for the detection of carbapenemase genes from rectal swabs, in a setting with endemic dissemination of carbapenemase-producing Enterobacteriaceae.在产碳青霉烯酶肠杆菌科细菌呈地方性传播的环境中，使用BD MAX™仪器和Check-Direct CPE实时荧光定量PCR检测直肠拭子中碳青霉烯酶基因的性能。
Diagn Microbiol Infect Dis. 2016 Sep;86(1):30-4. doi: 10.1016/j.diagmicrobio.2016.06.002. Epub 2016 Jun 7.

新德里金属β-内酰胺酶产生菌引起的血流感染在区域暴发期间的临床特征及转归

Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase-Producing During a Regional Outbreak.

作者信息

Falcone Marco, Tiseo Giusy, Antonelli Alberto, Giordano Cesira, Di Pilato Vincenzo, Bertolucci Pietro, Parisio Eva Maria, Leonildi Alessandro, Aiezza Noemi, Baccani Ilaria, Tagliaferri Enrico, Righi Lorenzo, Forni Silvia, Sani Spartaco, Mechi Maria Teresa, Pieralli Filippo, Barnini Simona, Rossolini Gian Maria, Menichetti Francesco

机构信息

Infectious Disease Unit, Azienda Ospedaliera Universitaria Pisana, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

出版信息

Open Forum Infect Dis. 2020 Jan 21;7(2):ofaa011. doi: 10.1093/ofid/ofaa011. eCollection 2020 Feb.

DOI:10.1093/ofid/ofaa011
PMID:32042848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7003035/
Abstract

Limited data about New Delhi metallo-β-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitro. Ceftazidime-avibactam plus aztreonam may represent a feasible therapeutic option.

摘要

关于新德里金属β-内酰胺酶（NDM）菌血症的资料有限。对40例NDM菌血症患者的血液分离株进行了抗生素敏感性和全基因组测序研究。NDM菌血症的30天死亡率很高。在大多数情况下，氨曲南-阿维巴坦在体外具有活性。头孢他啶-阿维巴坦加氨曲南可能是一种可行的治疗选择。