负载于纳米乳剂中的2'-羟基查耳酮对 种真菌的抗真菌活性
Antifungal activity of 2'-hydroxychalcone loaded in nanoemulsion against spp.
作者信息
Medina-Alarcón Kaila P, L Singulani Junya de, Dutra Luiz A, S Pitangui Nayla de, Pereira-da-Silva Marcelo A, Dos Santos Mariana B, Ayusso Gabriela M, Regasini Luis O, Soares Christiane P, Chorilli Marlus, Mendes-Giannini Maria Js, Fusco-Almeida Ana M
机构信息
Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara, Proteomics Center, Mycology Laboratory, Araraquara, SP, Brazil.
Structural Genomics Consortium, Research Institute-UNICAMP, Campinas, SP, Brasil.
出版信息
Future Microbiol. 2020 Jan;15:21-33. doi: 10.2217/fmb-2019-0095. Epub 2020 Feb 11.
This study aimed to evaluate the activity of 2'-hydroxychalcone-loaded in nanoemulsion (NLS + 2'chalc), the cytotoxic effect and toxicity against and using a zebrafish model. Preparation and physical-chemical characterization of nanoemulsion (NLS) and NLS + 2'chalc were performed. MIC and minimum fungicide concentration, cytotoxicity and toxicity were also evaluated in the model. NLS + 2'chalc showed fungicidal activity against spp. without cytotoxicity in MRC5 and HepG2 lines. It also had high selectivity index values and no toxicity in the zebrafish model based on MIC values. NLS + 2'chalc is a potential new alternative treatment for paracoccidioidomycosis.
本研究旨在使用斑马鱼模型评估纳米乳剂（NLS + 2'-查耳酮）中负载的2'-羟基查耳酮的活性、细胞毒性以及对[具体对象1]和[具体对象2]的毒性。进行了纳米乳剂（NLS）和NLS + 2'-查耳酮的制备及物理化学表征。还在[具体模型]中评估了最低抑菌浓度（MIC）和最低杀菌浓度、细胞毒性及毒性。NLS + 2'-查耳酮对[具体真菌种类]显示出杀菌活性，对MRC5和HepG2细胞系无细胞毒性。基于MIC值，它在斑马鱼模型中也具有高选择性指数值且无毒性。NLS + 2'-查耳酮是副球孢子菌病潜在的新替代治疗方法。
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