Cervini Ricardo, Centa Ariana, Locatelli Claudriana, Dal Pont Gustavo Colombo, Assolini João Paulo
Alto Vale do Rio Peixe University, Victor Baptista Adami Street, 800, Caçador, SC, 89500-000, Brazil.
Experimental Pathophysiology Research Group, Alto Vale do Rio Peixe University, Caçador, SC, Brazil.
Curr Microbiol. 2025 Apr 28;82(6):264. doi: 10.1007/s00284-025-04251-9.
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi of the genus Paracoccidioides. This disease is prevalent in Latin America, with Brazil being an endemic region. This mycosis can be classified as PCM infection, PCM disease and residual PCM. Although diagnosis and treatment exist, they have some limitations, and there is no vaccine available for this disease. Thus, the application of nanotechnology in the biomedical and health areas has become an innovative alternative. In this review, we highlight the main advances in the use of nanotechnology to improve and/or develop methods of diagnosis, treatment and vaccines for PCM. In order to improve diagnostic methods, nanoparticles can be used as biosensors associated with cell biology and spectroscopy techniques. The use of nanomaterials of different shapes and nature can act directly on the pathogen or as drug carriers, maintaining or improving antifungal activity and reducing toxicity in vitro and in vivo. In addition, nanoparticulate systems could be an important tool for vaccine development, stimulating a Th1 response, which is considered protective in PCM.
副球孢子菌病（PCM）是一种由副球孢子菌属真菌引起的系统性真菌病。这种疾病在拉丁美洲流行，巴西是一个 endemic 地区。这种真菌病可分为 PCM 感染、PCM 疾病和残留 PCM。尽管存在诊断和治疗方法，但它们有一些局限性，并且这种疾病没有可用的疫苗。因此，纳米技术在生物医学和健康领域的应用已成为一种创新的选择。在这篇综述中，我们强调了利用纳米技术改进和/或开发 PCM 诊断、治疗和疫苗方法的主要进展。为了改进诊断方法，纳米颗粒可用作与细胞生物学和光谱技术相关的生物传感器。使用不同形状和性质的纳米材料可以直接作用于病原体或作为药物载体，在体外和体内维持或提高抗真菌活性并降低毒性。此外，纳米颗粒系统可能是疫苗开发的重要工具，刺激 Th1 反应，这在 PCM 中被认为具有保护作用。
