吡格列酮激活大脑中的对氧磷酶 2：一种新的神经保护机制。
Pioglitazone activates paraoxonase-2 in the brain: A novel neuroprotective mechanism.
机构信息
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA.
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA.
出版信息
Exp Neurol. 2020 May;327:113234. doi: 10.1016/j.expneurol.2020.113234. Epub 2020 Feb 7.
Abstract
Paraoxonase-2 regulates reactive oxygen species production in mitochondria. Stimulating its expression has therapeutic potential for diseases where oxidative stress plays a significant role in the pathology. Evidence suggests that the anti-diabetic drug pioglitazone may provide neuroprotection in Parkinson's disease, Alzheimer's disease, brain trauma and ischemia, but the biochemical pathway(s) responsible has not been fully elucidated. Here we report that pioglitazone (10 mg/kg/day) for 5 days significantly increased paraoxonase-2 expression in mouse striatum. Thus, this result highlights paraoxonase-2 as a target for neuroprotective strategies and identifies pioglitazone as a tool to study the role of paraoxonase-2 in brain.
摘要
对氧磷酶 2 可调节线粒体中活性氧的产生。刺激其表达可能对氧化应激在病理中起重要作用的疾病具有治疗潜力。有证据表明，抗糖尿病药物吡格列酮可能在帕金森病、阿尔茨海默病、脑外伤和缺血中提供神经保护，但负责的生化途径尚未完全阐明。在这里，我们报告吡格列酮（每天 10 毫克/千克）治疗 5 天可显著增加小鼠纹状体中的对氧磷酶 2 表达。因此，这一结果突出了对氧磷酶 2 作为神经保护策略的靶点，并确定吡格列酮是研究对氧磷酶 2 在大脑中作用的工具。
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