Department of Echocardiography, The Affiliated Hospital of Qingdao University, Qingdao, China.
Department of respiration, Qingdao Municipal Hospital, Qingdao, China.
Echocardiography. 2020 Feb;37(2):317-322. doi: 10.1111/echo.14600. Epub 2020 Feb 11.
This study aimed to assess right ventricular (RV) diastolic dysfunction in patients with obstructive sleep apnea syndrome (OSAS) using velocity vector imaging (VVI) and to evaluate the application of VVI technology.
According to the apnea-hypopnea index (AHI), 69 patients with OSAS were divided into three groups: mild, moderate, and severe. A total of 35 cases of healthy subjects were enrolled as the control group. Digital images of apex four-chamber views were acquired to measure the peak early diastolic strain rate (RV-SRe), late diastolic strain rate(RV-SRa), and RV-SRe/RV-SRa using VVI.
RV-SRe, RV-Sra, and RV-SRe/RV-SRa were decreasing along with the disease severity. RV-SRe, RV-SRe/RV-SRa in moderate and severe OSAS group showed lower than control and mild OSAS groups. RV-SRa in severe OSAS group showed lower than control group. RV-SRe had the best correlation with AHI than other parameters.
Right ventricular diastolic dysfunction starts before the development of heart failure and pulmonary hypertension in patients with OSAS. RV-SRe was the parameter that may reflect subclinical myocardial dysfunction and can better reflect RV diastolic dysfunction.
本研究旨在使用速度向量成像（VVI）评估阻塞性睡眠呼吸暂停综合征（OSAS）患者的右心室（RV）舒张功能，并评估 VVI 技术的应用。
根据呼吸暂停低通气指数（AHI），将 69 例 OSAS 患者分为三组：轻度、中度和重度。共纳入 35 例健康受试者作为对照组。采集心尖四腔切面的数字图像，使用 VVI 测量峰值早期舒张应变率（RV-SRe）、晚期舒张应变率（RV-SRa）和 RV-SRe/RV-SRa。
RV-SRe、RV-SRa 和 RV-SRe/RV-SRa 随着疾病严重程度的增加而降低。中重度 OSAS 组的 RV-SRe 和 RV-SRe/RV-SRa 低于对照组和轻度 OSAS 组。重度 OSAS 组的 RV-SRa 低于对照组。RV-SRe 与 AHI 的相关性优于其他参数。
在 OSAS 患者出现心力衰竭和肺动脉高压之前，右心室舒张功能已经开始受损。RV-SRe 是反映亚临床心肌功能障碍的参数，能更好地反映 RV 舒张功能障碍。
