Department of Ophthalmology, The Kayseri City Hospital , Kayseri, Turkey.
Department of Internal Medicine, The Kayseri City Hospital , Kayseri, Turkey.
Curr Eye Res. 2020 Jul;45(7):873-878. doi: 10.1080/02713683.2020.1726406. Epub 2020 Feb 14.
The aim of the study was to assess the amplitude of accommodation (AA) in patients with type 1 diabetes mellitus (DM) and without diabetic retinopathy.
In two age- and sex-matched groups - one with twenty-nine eyes of 29 patients with type 1 DM, the other with twenty-nine eyes of 29 healthy individuals - retinal nerve fibre layer thickness and macular volume were determined by using optic coherence tomography in all quadrants, whereas AA was measured with the minus lens technique. The mean values of all three measurements were compared between the groups, and the effect of age, disease duration, (HbA1c and fasting blood glucose on AA were analysed using multiple regression analysis.
On average, participants were 25.0 ± 3.3 years old (range 19-30) in both groups ( 1.000), and patients had type 1 DM for an average of 13.0 ± 3.3 years. Mean AA in the right eye was 7.3 ± 1.1 D among patients and 8.1 ± 1.1 D among controls ( .005), as well as significantly negatively correlated with age in both groups ( = -0.735, .001 and = -0.819, .001, respectively) and disease duration among patients ( = -0.434, .019). In multivariable regression, age and disease duration significantly affected AA in patients, with an value of 0.623 ( .001 and .025, respectively). Average RNFL thickness was significantly different between the groups ( .014). Mean macular volumes for areas 1, 3 or 5 mm in diameter were similar between the groups.
AA was significantly lower among patients with type 1 DM than among healthy individuals, which suggests that the former might experience presbyopia earlier in life than the general population.
本研究旨在评估 1 型糖尿病（DM）患者且无糖尿病视网膜病变患者的调节幅度（AA）。
在年龄和性别匹配的两组患者中 - 一组为 29 例 1 型 DM 患者的 29 只眼，另一组为 29 例健康个体的 29 只眼 - 使用光学相干断层扫描（OCT）在所有象限测量视网膜神经纤维层厚度和黄斑体积，而 AA 则通过负透镜技术进行测量。比较两组之间所有三种测量值的平均值，并使用多元回归分析分析年龄、疾病持续时间、（HbA1c 和空腹血糖对 AA 的影响。
两组参与者的平均年龄分别为 25.0 ± 3.3 岁（范围 19-30 岁）（ 1.000），且患者患 1 型 DM 的平均时间为 13.0 ± 3.3 年。右眼患者的平均 AA 为 7.3 ± 1.1 D，对照组为 8.1 ± 1.1 D（.005），并且在两组中均与年龄呈显著负相关（ = -0.735，.001 和 = -0.819， .001，分别）和患者的疾病持续时间（ = -0.434， .019）。在多元回归中，年龄和疾病持续时间对患者的 AA 有显著影响， 值为 0.623（.001 和 .025，分别）。两组之间的平均 RNFL 厚度存在显著差异（.014）。直径为 1、3 或 5mm 的区域的平均黄斑体积在两组之间相似。
1 型 DM 患者的 AA 明显低于健康个体，这表明前者可能比一般人群更早经历老花眼。
