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肝硬化患者的解脲链球菌心内膜炎:一例报告

Streptococcus Gallolyticus endocarditis in patient with liver cirrhosis: a case report.

作者信息

Radovanovic Spurnić Aleksandra, Gmizić Ivana, Milošević Ivana, Petrović Olga, Obradović Danilo, Ristić Arsen, Stevanović Olja

机构信息

Clinic for Infectious and Tropical Diseases, Clinical Center of Serbia, Belgrade, Serbia.

Cardiology Clinic, Clinical Center of Serbia, Belgrade, Serbia.

出版信息

J Infect Dev Ctries. 2019 Apr 30;13(4):352-356. doi: 10.3855/jidc.11126.

Abstract

Streptococcus gallolyticus (S. gallolyticus) bacteremia is commonly associated with endocarditis and diseases of gastrointestinal tract, especially with colorectal carcinoma. On the other side, it is rarely connected to liver disease, especially alcoholic liver disease. A 44-old patient with a history of one month fever, pre-existing heart murmur and previous alcohol abuse, was treated in Clinic for Infectious and tropical diseases, Clinical Centre of Serbia (CCS), Belgrade. The diagnose of infective endocarditis (IE) of the aortic valve caused by S. gallolyticus has been established. Despite the conducted antibiotic treatment based on antibiogram, pericardial effusion with paracardial aortic abscess was diagnosed on the 9th day of treatment. Pericardiocentesis was done and 800 mL of haemorrhagic fluid was evacuated in the Clinic for Cardiology, CCS. Unfortunately, 20th day of hospitalization the patient died. Clinical autopsy confirmed endocarditis, liver cirrhosis and chronic pericarditis. Prognosis of the outcome of treatment of patient with endocarditis caused S. gallolyticus and liver cirrhosis is not optimistic. Therefore, significant attention should be given to patients with liver cirrhosis and febrile of unknown origin.

摘要

解脲链球菌菌血症通常与心内膜炎和胃肠道疾病相关,尤其是与结直肠癌有关。另一方面,它很少与肝脏疾病相关,特别是酒精性肝病。一名44岁的患者,有一个月发热病史、既往心脏杂音和既往酗酒史,在塞尔维亚临床中心(CCS)贝尔格莱德传染病和热带病诊所接受治疗。已确诊为由解脲链球菌引起的主动脉瓣感染性心内膜炎(IE)。尽管根据药敏试验进行了抗生素治疗,但在治疗的第9天诊断出心包积液伴心包旁主动脉脓肿。在CCS心脏病诊所进行了心包穿刺,抽出了800毫升血性液体。不幸的是,住院第20天患者死亡。临床尸检证实有心内膜炎、肝硬化和慢性心包炎。解脲链球菌引起的心内膜炎和肝硬化患者的治疗预后不容乐观。因此,对于肝硬化和不明原因发热的患者应给予高度关注。

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