Department of Psychology, University of Bath, Bath, UK.
Department of Psychology, University of Bath, Bath, UK.
Neuroimage. 2020 May 1;211:116628. doi: 10.1016/j.neuroimage.2020.116628. Epub 2020 Feb 8.
Fast periodic visual stimulation (FPVS) has recently emerged as a powerful new tool in cognitive neuroscience. Capable of measuring a range of cognitive functions in single subjects in just minutes of recording time, it has been adapted to measure visual, semantic and linguistic processing. We present a new adaptation of the FPVS approach to measure recognition memory via old/new contrasts. Twenty one subjects (23 (±6) yrs, 7 males) completed an FPVS-oddball paradigm that assessed their spontaneous ability to differentiate between rapidly presented images on the basis of a pre-FPVS encoding task, i.e. oddball stimuli were only defined by the subject's experimentally induced memory of them. A clear oddball detection response reflecting recognition memory was observed within one minute of EEG recording time, simply through the passive viewing of stimuli, i.e. subjects received no task instructions and provided no behavioural response. Performance on a subsequent behavioural recognition task showed high levels of recognition of the oddball stimuli. As such, the FPVS approach returned an objective, non-verbal measure of recognition memory in just one minute of recording time, free from the confounds of behavioural recognition tasks. This finding reinforces the adaptability of the FPVS approach for the examination of higher-level cognition and provides a new method for the neural measurement of recognition memory.
快速周期性视觉刺激（FPVS）最近成为认知神经科学中的一种强大新工具。它能够在短短几分钟的记录时间内测量单个受试者的一系列认知功能，已经被改编用于测量视觉、语义和语言处理。我们提出了一种新的 FPVS 方法来通过旧/新对比来测量识别记忆。21 名受试者（23（±6）岁，7 名男性）完成了 FPVS-oddball 范式，该范式评估了他们在基于 FPVS 编码任务的快速呈现图像之间自发区分的能力，即，oddball 刺激仅通过受试者对它们的实验诱导记忆来定义。在 EEG 记录时间不到一分钟的时间内，观察到了清晰的反映识别记忆的 oddball 检测反应，只需被动观察刺激，即，受试者没有收到任务指令，也没有提供行为反应。在随后的行为识别任务上的表现表明，oddball 刺激得到了高度识别。因此，FPVS 方法在不到一分钟的记录时间内返回了识别记忆的客观、非言语测量，没有行为识别任务的混杂。这一发现增强了 FPVS 方法在高级认知检查中的适应性，并为识别记忆的神经测量提供了一种新方法。
