Bombardier C
Rheumatic Disease Unit, Wellesley Hospital, Toronto, ON, Canada.
J Rheumatol Suppl. 1988 Oct;17:5-8.
This paper provides an overview of the epidemiological techniques used in pharmacoepidemiology. Definitions, advantages and disadvantages of the various types of study design are presented and potential sources of bias are discussed. An important challenge and the source of major controversies is the evaluation of cause and effect relationships when exposure to a drug is associated with the occurrence of an adverse event; we present an established set criteria suggesting inferences about causation.
本文概述了药物流行病学中使用的流行病学技术。介绍了各类研究设计的定义、优缺点，并讨论了潜在的偏倚来源。当接触一种药物与不良事件的发生相关联时，因果关系的评估是一个重要挑战和主要争议的来源；我们提出了一套既定的标准，用于对因果关系进行推断。
