Department of Orthopedics, University of Louisville, Louisville, KY.
J Arthroplasty. 2020 Mar;35(3S):S35-S39. doi: 10.1016/j.arth.2019.10.033. Epub 2019 Oct 23.
Antibiotic spacers play a significant role in the treatment of periprosthetic joint infections. They help maintain soft-tissue tension and provide delivery of high dose of antibiotics to the local tissue. The use of static or dynamic spacers is based on multiple factors including the extent of soft-tissue, ligamentous and bone compromise, overall patient function, comorbid conditions, and virulence of the organism. There is no difference in reinfection incidence between static vs dynamic spacers following two-stage reimplantation. Static spacers can be customized to treat all cases of periprosthetic total knee infections and offer intraoperative flexibility to vary the cement quantity and amount of antibiotics in the spacer to provide high-dose local delivery of antibiotics to address the dead space, bone loss, and soft-tissue compromise. Static spacers are especially advantageous in cases of extensor mechanism and ligamentous compromise where articulating spacers may not be able to provide adequate stability.
抗生素间隔物在治疗假体周围关节感染方面起着重要作用。它们有助于维持软组织张力,并为局部组织提供高剂量的抗生素。静态或动态间隔物的使用基于多种因素,包括软组织、韧带和骨骼损伤的程度、患者整体功能、合并症和病原体的毒力。在两阶段再植入后,静态与动态间隔物在再感染发生率方面没有差异。静态间隔物可定制用于治疗所有假体周围全膝关节感染病例,并在手术过程中提供灵活性,可改变水泥量和间隔物中的抗生素量,以提供高剂量的局部抗生素递送,以解决死腔、骨丢失和软组织损伤。在伸肌机制和韧带损伤的情况下,静态间隔物特别有利,因为关节间隔物可能无法提供足够的稳定性。