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评价 II-IV 型食管裂孔疝(POH)外科修补术对肺功能改善影响的研究:系统评价和荟萃分析。

Critical appraisal of the impact of surgical repair of type II-IV paraoesophageal hernia (POH) on pulmonary improvement: A systematic review and meta-analysis.

机构信息

Northern Oesophagogastric Unit, Royal Victoria Infirmary, Newcastle University NHS Foundation Trust Hospitals, Newcastle Upon Tyne, UK; Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK.

Northern Oesophagogastric Unit, Royal Victoria Infirmary, Newcastle University NHS Foundation Trust Hospitals, Newcastle Upon Tyne, UK.

出版信息

Surgeon. 2020 Dec;18(6):365-374. doi: 10.1016/j.surge.2020.01.006. Epub 2020 Feb 8.

Abstract

BACKGROUND

Paraoesophageal hernia (POH) comprising type II-IV hiatal hernia often presents with pulmonary symptoms such as shortness of breath. However, impact of surgical repair on improvement in pulmonary symptoms is unclear.

OBJECTIVE

This systematic review and meta-analysis aimed at characterising impact of POH repair on patient reported improvement in pulmonary symptoms.

METHODS

This systematic review identified studies reported pulmonary symptoms in patients with undergoing surgical repair for Type II-IV POH from 1st January 2001 to 1st December 2018. Primary outcome was improvement in pulmonary symptoms. Secondary outcomes were improvement in other patient-reported outcomes such as heartburn, regurgitation, chest pain, and dysphagia and intraoperative and postoperative outcomes.

RESULTS

This systematic review identified 27 studies (n = 4428 patients) reporting assessment of pulmonary symptoms. However, only 21 studies (n = 2902 patients) reported preoperative and postoperative pulmonary symptoms and hence these were included in the final meta-analysis. There was significant improvement in pulmonary symptoms following POH repair (OR: 8.40, CI: 4.91-14.35, p < 0.001), with improvement in all types of POH. Rates of overall and major complications were 16% and 5%, respectively. Rates of conversion, 30-day mortality, reoperation and recurrence were 2%, 1% 4% and 12% respectively.

CONCLUSION

This review demonstrates that POH repair is associated with improvement in pulmonary symptoms with acceptable low laparoscopic conversion rates, morbidity, mortality and recurrence rates.

摘要

背景

食管裂孔疝(POH)包括 II-IV 型食管裂孔疝,常表现为呼吸急促等肺部症状。然而,手术修复对改善肺部症状的影响尚不清楚。

目的

本系统评价和荟萃分析旨在描述 POH 修复对患者报告的肺部症状改善的影响。

方法

本系统评价从 2001 年 1 月 1 日至 2018 年 12 月 1 日,确定了对接受 II-IV 型 POH 手术修复的患者报告肺部症状的研究。主要结局是肺部症状的改善。次要结局是改善其他患者报告的结局,如烧心、反流、胸痛和吞咽困难,以及术中及术后结局。

结果

本系统评价确定了 27 项研究(n=4428 例患者)报告了肺部症状评估。然而,只有 21 项研究(n=2902 例患者)报告了术前和术后的肺部症状,因此这些研究被纳入最终的荟萃分析。POH 修复后肺部症状显著改善(OR:8.40,CI:4.91-14.35,p<0.001),所有类型的 POH 均有改善。总体和主要并发症的发生率分别为 16%和 5%。转换率、30 天死亡率、再次手术率和复发率分别为 2%、1%、4%和 12%。

结论

本综述表明,POH 修复与肺部症状改善相关,腹腔镜转换率、发病率、死亡率和复发率较低。

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