Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos #07-01, Singapore, 138669, Singapore.
ChemSusChem. 2020 Apr 7;13(7):1740-1745. doi: 10.1002/cssc.201903180. Epub 2020 Mar 6.
Selective cleavage of the β-O-4 ether bond of lignin to produce aromatics is one of the most important topics for the sustainable production of chemicals from biomass. A simple system has been developed for C -C bond cleavage of a β-O-4 ketone-structured lignin model compound (LMC) by H O in formic acid under metal catalyst-free conditions. By using this simple system, with H O , formic acid, and mineral acid catalyst, over 90 % product yield is achieved in 6 h at room temperature. The reaction proceeds through the classic Baeyer-Villiger oxidation and in situ-generated performic acid serves as the key oxidant. The cleavage of alcoholic LMCs by using the presented method in a two-step process is also demonstrated.
选择性断裂木质素β-O-4 醚键以生产芳烃是从生物质可持续生产化学品的最重要课题之一。本文在无金属催化剂条件下，在甲酸中利用 H O 开发了一种简单的系统，用于β-O-4 酮结构木质素模型化合物（LMC）的 C -C 键断裂。通过使用该简单系统，在室温下以 H O 、甲酸和矿物酸催化剂反应 6 小时，即可获得超过 90%的产物收率。该反应通过经典的 Baeyer-Villiger 氧化进行，原位生成的过甲酸是关键氧化剂。通过两步法，该方法还可用于醇型 LMC 的断裂。
